Mountain-cultivated ginseng protects against cognitive impairments in aged GPx-1 knockout mice via activation of Nrf2/ChAT/ERK signaling pathway
DC Field | Value | Language |
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dc.contributor.author | Nguyen, B.T. | - |
dc.contributor.author | Shin, E.-J. | - |
dc.contributor.author | Jeong, J.H. | - |
dc.contributor.author | Sharma, N. | - |
dc.contributor.author | Tran, N.K.C. | - |
dc.contributor.author | Nguyen, Y.N.D. | - |
dc.contributor.author | Kim, D.-J. | - |
dc.contributor.author | Wie, M.B. | - |
dc.contributor.author | Lee, Y. | - |
dc.contributor.author | Byun, J.K. | - |
dc.contributor.author | Ko, S.K. | - |
dc.contributor.author | Nah, S.-Y. | - |
dc.contributor.author | Kim, H.-C. | - |
dc.date.accessioned | 2024-01-17T05:00:29Z | - |
dc.date.available | 2024-01-17T05:00:29Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.issn | 2093-4947 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70992 | - |
dc.description.abstract | Background: Escalating evidence shows that ginseng possesses an antiaging potential with cognitive enhancing activity. As mountain cultivated ginseng (MCG) is cultivated without agricultural chemicals, MCG has emerged as a popular herb medicine. However, little is known about the MCG-mediated pharmacological mechanism on brain aging. Methods: As we demonstrated that glutathione peroxidase (GPx) is important for enhancing memory function in the animal model of aging, we investigated the role of MCG as a GPx inducer using GPx-1 (a major type of GPx) knockout (KO) mice. We assessed whether MCG modulates redox and cholinergic parameters, and memory function in aged GPx-1 knockout KOmice. Results: Redox burden of aged GPx-1 KO mice was more evident than that of aged wild-type (WT) mice. Alteration of Nrf2 DNA binding activity appeared to be more evident than that of NFκB DNA binding activity in aged GPx-1 KO mice. Alteration in choline acetyltransferase (ChAT) activity was more evident than that in acetylcholine esterase activity. MCG significantly attenuated reductions in Nrf2 system and ChAT level. MCG significantly enhanced the co-localization of Nrf2-immunoreactivity and ChAT-immunoreactivity in the same cell population. Nrf2 inhibitor brusatol significantly counteracted MCG-mediated up-regulation in ChAT level and ChAT inhibition (by k252a) significantly reduced ERK phosphorylation by MCG, suggesting that MCG might require signal cascade of Nrf2/ChAT/ERK to enhance cognition. Conclusion: GPx-1 depletion might be a prerequisite for cognitive impairment in aged animals. MCG-mediated cognition enhancement might be associated with the activations of Nrf2, ChAT, and ERK signaling cascade. © 2023 | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Mountain-cultivated ginseng protects against cognitive impairments in aged GPx-1 knockout mice via activation of Nrf2/ChAT/ERK signaling pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jgr.2023.01.005 | - |
dc.identifier.bibliographicCitation | Journal of Ginseng Research, v.47, no.4, pp 561 - 571 | - |
dc.identifier.kciid | ART003016127 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001024507700001 | - |
dc.identifier.scopusid | 2-s2.0-85148756198 | - |
dc.citation.endPage | 571 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 561 | - |
dc.citation.title | Journal of Ginseng Research | - |
dc.citation.volume | 47 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | aged GPx-1 knockout mice | - |
dc.subject.keywordAuthor | aging-induced cognitive impairments | - |
dc.subject.keywordAuthor | hippocampus | - |
dc.subject.keywordAuthor | mountain cultivated ginseng | - |
dc.subject.keywordAuthor | Nrf2/ChAT/ERK signaling cascade | - |
dc.subject.keywordPlus | CELLULAR GLUTATHIONE-PEROXIDASE | - |
dc.subject.keywordPlus | KINASE-C-DELTA | - |
dc.subject.keywordPlus | RE PROTECTS | - |
dc.subject.keywordPlus | MITOCHONDRIAL DYSFUNCTION | - |
dc.subject.keywordPlus | ABNORMAL BEHAVIORS | - |
dc.subject.keywordPlus | OXIDATIVE DAMAGE | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | PHENCYCLIDINE | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | MODULATION | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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