Analysis of Mortality in Intracerebral Hemorrhage Patients with Hyperacute Ischemic Stroke Treated Using Thrombolytic Therapy: A Nationwide Population-Based Cohort Study in South Koreaopen access
- Authors
- Choi, Hyun-Young; Cho, Yongil; Kim, Wonhee; Minn, Yang-Ki; Kang, Gu-Hyun; Jang, Yong-Soo; Lee, Yoonje; Kim, Jae-Guk; Kim, Jihoon; Cho, Youngsuk; Shin, Hyungoo; Moon, Shinje; Ahn, Chiwon; Lee, Juncheol; Shin, Dong-Geum; Park, Jae-Keun
- Issue Date
- Aug-2022
- Publisher
- MDPI
- Keywords
- ischemic stroke; thrombolytic therapy; cerebral hemorrhage; mortality; cohort studies
- Citation
- JOURNAL OF PERSONALIZED MEDICINE, v.12, no.8
- Journal Title
- JOURNAL OF PERSONALIZED MEDICINE
- Volume
- 12
- Number
- 8
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71035
- DOI
- 10.3390/jpm12081260
- ISSN
- 2075-4426
2075-4426
- Abstract
- This study investigated the impact of intracerebral hemorrhage (ICH) on the cumulative mortality of patients with hyperacute ischemic stroke. This population-based retrospective cohort study used claims data from the National Health Insurance Service customized database of South Korea. The recruitment period was 2005-2018. The study population included patients with hyperacute ischemic stroke who had received intravenous thrombolysis. The primary end-point was 12-month cumulative mortality, which was analyzed in both the ICH and no-ICH groups. Of the 50,550 patients included, 2567 (5.1%) and 47,983 (94.9%) belonged to the ICH and no-ICH groups, respectively. In the univariable analysis for 12-month mortality, ICH patients were substantially more prevalent among dead patients than among patients who survived (11.6% versus 3.6%; p < 0.001). The overall 12-month cumulative mortality rate was 18.8%. Mortality in the ICH group was higher than that in the no-ICH group (42.8% versus 17.5%; p < 0.001). In the multivariable analysis, the risk of 12-month cumulative mortality was 2.97 times higher in the ICH group than in the no-ICH group (95% confidence interval, 2.79-3.16). The risk of 12-month cumulative mortality in hyperacute ischemic stroke can increase approximately threefold after the occurrence of spontaneous ICH following intravenous thrombolysis.
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