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Wound healing effect of visible light-curable chitosan with encapsulated EGF

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dc.contributor.authorPark, Shin-Hye-
dc.contributor.authorKim, Eun-Hye-
dc.contributor.authorLee, Hyung-Jae-
dc.contributor.authorHeo, Yun-
dc.contributor.authorCho, Young-Min-
dc.contributor.authorSeo, Si-Yoong-
dc.contributor.authorKim, Tae-Yeon-
dc.contributor.authorSuh, Hyeun-Woo-
dc.contributor.authorKim, Mi-Kyung-
dc.contributor.authorIto, Yoshihiro-
dc.contributor.authorNah, Jae-Woon-
dc.contributor.authorSon, Tae-Il-
dc.date.available2019-03-08T13:36:23Z-
dc.date.issued2016-04-
dc.identifier.issn1598-5032-
dc.identifier.issn2092-7673-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7107-
dc.description.abstractLow molecular O-carboxymethyl chitosan, a derivative of chitosan, was conjugated with a hydrophilic carboxymethyl group, following which the conjugate was modified with a furfuryl group. The chitosan derivative was cross-linked to encapsulate a model protein, bovine serum albumin (BSA), in the presence of Rose Bengal under visible light irradiation. The encapsulated BSA was slowly released from the matrix over 2 weeks. The modified chitosan exhibited antimicrobial activity and was non-cytotoxic to NIH3T3 fibroblasts. The wound healing effect of the cross-linked chitosan derivative was examined in Sprague-Dawley rats at 3, 7, and 14 days post-wounding. Cross-linked and murine epidermal growth factor (mEGF)-encapsulated chitosan derivatives healed wounds more rapidly in rats than non-encapsulated mEGF or chitosan derivative alone. Thus, visible light-curable chitosan has good potential for application as wound-healing matrix.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisherSPRINGER-
dc.titleWound healing effect of visible light-curable chitosan with encapsulated EGF-
dc.typeArticle-
dc.identifier.doi10.1007/s13233-016-4050-4-
dc.identifier.bibliographicCitationMACROMOLECULAR RESEARCH, v.24, no.4, pp 336 - 341-
dc.identifier.kciidART002100930-
dc.description.isOpenAccessN-
dc.identifier.wosid000374902700006-
dc.identifier.scopusid2-s2.0-84964462198-
dc.citation.endPage341-
dc.citation.number4-
dc.citation.startPage336-
dc.citation.titleMACROMOLECULAR RESEARCH-
dc.citation.volume24-
dc.type.docTypeArticle-
dc.publisher.location대한민국-
dc.subject.keywordAuthorchitosan-
dc.subject.keywordAuthorwound healing-
dc.subject.keywordAuthorprotein encapsulation-
dc.subject.keywordAuthorepidermal growth factor-
dc.subject.keywordAuthorvisible light-curable-
dc.subject.keywordPlusBIOMEDICAL APPLICATIONS SYNTHESIS-
dc.subject.keywordPlusMOLECULAR-WEIGHT CHITOSAN-
dc.subject.keywordPlusIN-VITRO BIOCOMPATIBILITY-
dc.subject.keywordPlusCARBOXYMETHYL CHITOSAN-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusANTIBACTERIAL ACTIVITY-
dc.subject.keywordPlusANTIADHESION AGENT-
dc.subject.keywordPlusTITANIUM PLATE-
dc.subject.keywordPlusFISH GELATIN-
dc.subject.keywordPlusDRESSINGS-
dc.relation.journalResearchAreaPolymer Science-
dc.relation.journalWebOfScienceCategoryPolymer Science-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
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