Wound healing effect of visible light-curable chitosan with encapsulated EGF
- Authors
- Park, Shin-Hye; Kim, Eun-Hye; Lee, Hyung-Jae; Heo, Yun; Cho, Young-Min; Seo, Si-Yoong; Kim, Tae-Yeon; Suh, Hyeun-Woo; Kim, Mi-Kyung; Ito, Yoshihiro; Nah, Jae-Woon; Son, Tae-Il
- Issue Date
- Apr-2016
- Publisher
- SPRINGER
- Keywords
- chitosan; wound healing; protein encapsulation; epidermal growth factor; visible light-curable
- Citation
- MACROMOLECULAR RESEARCH, v.24, no.4, pp 336 - 341
- Pages
- 6
- Journal Title
- MACROMOLECULAR RESEARCH
- Volume
- 24
- Number
- 4
- Start Page
- 336
- End Page
- 341
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7107
- DOI
- 10.1007/s13233-016-4050-4
- ISSN
- 1598-5032
2092-7673
- Abstract
- Low molecular O-carboxymethyl chitosan, a derivative of chitosan, was conjugated with a hydrophilic carboxymethyl group, following which the conjugate was modified with a furfuryl group. The chitosan derivative was cross-linked to encapsulate a model protein, bovine serum albumin (BSA), in the presence of Rose Bengal under visible light irradiation. The encapsulated BSA was slowly released from the matrix over 2 weeks. The modified chitosan exhibited antimicrobial activity and was non-cytotoxic to NIH3T3 fibroblasts. The wound healing effect of the cross-linked chitosan derivative was examined in Sprague-Dawley rats at 3, 7, and 14 days post-wounding. Cross-linked and murine epidermal growth factor (mEGF)-encapsulated chitosan derivatives healed wounds more rapidly in rats than non-encapsulated mEGF or chitosan derivative alone. Thus, visible light-curable chitosan has good potential for application as wound-healing matrix.
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- Appears in
Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
- College of Medicine > College of Medicine > 1. Journal Articles
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