Current Trends in Liquid Biopsy Technology for Early Diagnosis of Metastatic Renal Cell Carcinomaopen access전이성 신장세포암 조기 진단을 위한 액체 생검 기술의 최신 동향
- Authors
- 서정윤(Suh Jeongyoon); 맹세정; 김미리내; 강수정; 최영욱; 장인호
- Issue Date
- 2022
- Publisher
- 대한비뇨기종양학회
- Keywords
- Liquid biopsy; Prognostic markers; Renal cell carcinoma; Tumor biomarker
- Citation
- 대한비뇨기종양학술지, v.20, no.4, pp 223 - 234
- Pages
- 12
- Journal Title
- 대한비뇨기종양학술지
- Volume
- 20
- Number
- 4
- Start Page
- 223
- End Page
- 234
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71091
- DOI
- 10.22465/kjuo.2022.20.4.223
- ISSN
- 2234-4977
- Abstract
- Clear cell renal cell carcinoma (ccRCC) is a disease with a wide variety of clinical progressions such as the rate of disease progression or the degree of metastasis. About 30% of ccRCC patients suffer from metastatic diseases, and about 30% develop metastasis after diagnosis. In the case of metastatic RCC, early prediction of the disease is important because of the poor prognosis, but ccRCC-specific molecular markers for clinical use are not available yet. As an alternative, liquid biopsy, which can find molecules released from tumor tissues in circulating blood and obtain information on metastatic dissemination and recurrence of ccRCC, is emerging. In this article, we will introduce molecules such as cell free DNA, cell free RNA, protein, and exosomes available as circulating biomarkers for liquid biopsy. We will also introduce some promising technologies that can compensate for the limitations of liquid biopsy.
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