Clinicopathologic Analysis of the Liver Explant with Severe Hepatitis A Virus Infectionopen access
- Authors
- Kim, Joo Young; Lee, Sung Gyu; Hwang, Shin; Kim, Ji-Hoon; Jang, Se-Jin; Yu, Eunsil
- Issue Date
- Jul-2011
- Publisher
- KOREAN SOCIETY PATHOLOGISTS
- Keywords
- HAV infection; Liver transplantation; Cholestasis; Venulitis
- Citation
- KOREAN JOURNAL OF PATHOLOGY, v.45, pp S48 - S52
- Journal Title
- KOREAN JOURNAL OF PATHOLOGY
- Volume
- 45
- Start Page
- S48
- End Page
- S52
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71152
- DOI
- 10.4132/KoreanJPathol.2011.45.S1.S48
- ISSN
- 1738-1843
2092-8920
- Abstract
- The incidence of severe hepatitis A virus (HAV) infection has been increasing. However, clinicopathologic features of severe HAV infection that lead to liver transplantation (LT) have not been reported in Korea. We retrieved 16 LT cases with HAV infection during the last 3 years at Asan Medical Center, Seoul, Korea. Fifteen cases progressed to hepatic encephalopathy. Thirteen cases survived with or without complications, and three patients died of sepsis. The explanted liver showed massive or zonal necrosis with moderate to severe cholestasis. The zonal distribution of necrosis was frequently associated with endothelialitis of portal and/or central veins. Degenerative changes of hepatocytes were various in degree and distribution. Viral inclusions were suspected in two cases. Although HAV infection is usually confirmed by serological tests, significant venulitis of central and/or portal veins and viral inclusions, which are rarely observed, can suggest an HAV infection as a cause of massive hepatic necrosis of unknown mechanism.
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