Low MST1/2 and negative LATS1/2 expressions are associated with poor prognosis of colorectal cancers
- Authors
- Jung, Jiyoon; Kim, Jeong Won; Kim, Gilhyang; Kim, Joo Young
- Issue Date
- Aug-2023
- Publisher
- ELSEVIER GMBH
- Keywords
- Colorectal cancer; MST1/2; LATS1/2; Hippo; Prognosis
- Citation
- PATHOLOGY RESEARCH AND PRACTICE, v.248
- Journal Title
- PATHOLOGY RESEARCH AND PRACTICE
- Volume
- 248
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71173
- DOI
- 10.1016/j.prp.2023.154608
- ISSN
- 0344-0338
1618-0631
- Abstract
- Mammalian STe20-like protein kinase 1/2 (MST1/2) and large tumor suppressor homolog 1/2 (LATS1/2) are the core components of the tumor-suppressive Hippo pathway. Dysregulation of this pathway is associated with the progression and metastasis of various cancers. However, MST1/2 and LATS1/2 expressions have not been systematically evaluated in colorectal cancers. We evaluated the clinicopathologic correlation and prognostic significance of MST1/2 and LATS1/2 immunohistochemical expressions in 327 colorectal cancer patients. Low MST1/2 expression, identified in 235 (71.9 %) cases, was significantly associated with poor differentiation (P = 0.018) and large size (P < 0.001) of the tumor. Negative LATS1/2 expression, identified in 226 (69.1 %) cases, was significantly correlated with low MST1/2 expression (P = 0.044). Low MST1/2 and negative LATS1/2 expressions were significantly associated with poor overall survivals (P = 0.015 and P = 0.038, respectively). Furthermore, the combined MST1/2lowLATS1/2negative expression group showed significantly worse overall survival than other groups (P = 0.003), and considered as an independent poor prognostic factor for colorectal cancer patients (hazard ratio = 1.720; 95 % confidence interval, 1.143-2.588; P = 0.009). Low MST1/2 and negative LATS1/2 expressions may serve as prognostic indicators in patients with colorectal cancer.
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