Superficial Vein Thrombosis as the Initial Manifestation of Protein S Deficiency in an Adolescent with Narcolepsy

Abstract

Protein S (PS) deficiency and narcolepsy have a similar pathomechanism in view of autoimmunity, and they can develop following an infection. However, there is no previous report of a patient with narcolepsy associated with PS deficiency and the relationship between these two diseases has not yet been investigated. PS deficiency may lead to coagulopathies, which can present as superficial or deep vein thrombosis and embolism. Therefore, here we describe a case of an 18-year-old man with narcolepsy who presented with superficial vein thrombosis associated with PS deficiency. Our case suggested that the development of PS deficiency and narcolepsy can be interrelated with each other.