Increased oligomeric TDP-43 in the plasma of Korean frontotemporal dementia patients with semantic dementia
- Authors
- Jamerlan, Angelo M.; Shim, Kyu Hwan; Youn, Young Chul; Teunissen, Charlotte; An, Seong Soo A.; Scheltens, Philip; Kim, SangYun
- Issue Date
- Sep-2023
- Publisher
- John Wiley and Sons Inc
- Keywords
- aggregation; antibodies; diagnosis; elisa; epitope; immunoassay; monomer; multimer detection system; oligomer; semantic dementia; TDP-43
- Citation
- Alzheimer's and Dementia, v.19, no.9, pp 4020 - 4027
- Pages
- 8
- Journal Title
- Alzheimer's and Dementia
- Volume
- 19
- Number
- 9
- Start Page
- 4020
- End Page
- 4027
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71575
- DOI
- 10.1002/alz.13127
- ISSN
- 1552-5260
1552-5279
- Abstract
- INTRODUCTION: Semantic dementia (SD) is a progressive neurodegenerative disease associated with impaired vocabulary that progresses to memory impairment. Post-mortem immunohistochemical analysis is the current reliable method of differentiating TDP-43 deposits in cortical tissue; no means of antemortem diagnosis exists in biofluids, let alone in plasma. METHODS: Here the multimer detection system (MDS) was used to quantify the oligomeric TDP-43 (o-TDP-43) concentrations in plasma of Korean SD patients (n = 16, 6 male, 10 female, ages 59–87). The o-TDP-43 concentrations were compared with the total TDP-43 (t-TDP-43) concentrations quantified through conventional enzyme-linked immunosorbent assay (ELISA). RESULTS AND DISCUSSION: Only MDS showed a significant increase in o-TDP-43 concentrations in the plasma of patients with SD compared to other neurodegenerative disorders and normal controls (p < 0.05). Based on these results, o-TDP-43 concentrations through the application of MDS may be a useful plasma biomarker in SD-FTD (frontotemporal dementia) diagnosis. © 2023 the Alzheimer's Association.
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