The Effect of Preoperative Antiplatelet Therapy on Hemorrhagic Complications after Decompressive Craniectomy in Patients with Traumatic Brain Injuryopen access
- Authors
- 한호균; 고은정; 최현호; 김병철; 양승엽; 조근태
- Issue Date
- Nov-2016
- Publisher
- 대한신경손상학회
- Keywords
- Brain injuries; Decompressive craniectomy; Platelet aggregation inhibitors; Postoperative hemorrhage
- Citation
- Korean Journal of Neurotrauma, v.12, no.2, pp 61 - 66
- Pages
- 6
- Journal Title
- Korean Journal of Neurotrauma
- Volume
- 12
- Number
- 2
- Start Page
- 61
- End Page
- 66
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71612
- DOI
- 10.13004/kjnt.2016.12.2.61
- ISSN
- 2234-8999
2288-2243
- Abstract
- Objective: Traditionally, it is generally recommended that antiplatelet agent should be discontinued before surgery. However, decompressive craniectomy (DC) in patients with traumatic brain injury (TBI) is performed emergently in most cases. Therefore, DC cannot be delayed to the time when the effect of antiplatelet agent on bleeding tendency dissipates. In this study, we evaluated the effect of preinjury antiplatelet therapy on hemorrhagic complications after emergent DC in patients with TBI.
Methods: We retrospectively investigated patients with TBI who underwent emergent DC between 2006 and 2015. The patients were separated into two groups according to the use of preinjury antiplatelet agent: group 1 (patients taking antiplatelet agent) and group 2 (patients not taking antiplatelet agent). The rate of hemorrhagic complications (postoperative epidural or subdural hemorrhage, newly developed, or progression of preexisting contusion or intracerebral hemorrhage within the field of DC) and the rate of reoperation within 7 days after DC were compared between two groups.
Results: During the study period, DC was performed in 90 patients. Of them, 19 patients were taking antiplatelet agent before TBI. The rate of hemorrhagic complications was 52.6% (10/19) in group 1 and 46.5% (33/71) in group 2 (p=0.633). The rate of reoperation was 36.8% (7/19) in group 1 and 36.6% (26/71) in group 2 (p=0.986). No statistical difference was found between two groups.
Conclusion: Preinjury antiplatelet therapy did not influence the rate of hemorrhagic complications and reoperation after DC. Emergent DC in patients with TBI should not be delayed because of preinjury antiplatelet therapy.
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