The Natural Substance MS-10 Improves and Prevents Menopausal Symptoms, Including Colpoxerosis, in Clinical Research
- Authors
- Noh, Yoo-Hun; Kim, Do-Hee; Lee, Seung-Ah; Yin, Xing Fu; Park, Jiae; Lee, Moo Yeol; Lee, Won Bok; Lee, Sang Hyung; Kim, Jae Kwang; Kim, Sung-Su; Jeong, Yoonhwa; Myung, Soon-Chul; Kim, Tae Jin; Kang, Il-Jun
- Issue Date
- Mar-2016
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- menopause; colpoxerosis; Kupperman's Index; ovariectomized rat; MS-10
- Citation
- JOURNAL OF MEDICINAL FOOD, v.19, no.3, pp 228 - 237
- Pages
- 10
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 19
- Number
- 3
- Start Page
- 228
- End Page
- 237
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7176
- DOI
- 10.1089/jmf.2015.3547
- ISSN
- 1096-620X
1557-7600
- Abstract
- Many natural substances were screened to develop nutraceuticals that reduce menopausal symptoms. A complex of Cirsium japonicum var. maackii and Thymus vulgaris extracts, named MS-10, had significant positive effects. Under a low concentration of estrogen, which represents postmenopausal physiological conditions, MS-10 had beneficial effects on estrogen receptor-expressing MCF-7 cells by reversibly enhancing estrogen activity. In addition, in the ovariectomized rat model, changes in bone-specific alkaline phosphatase activity and osteocalcin, as well as low-density lipoprotein cholesterol and triglyceride levels were significantly decreased by MS-10. These results show that MS-10 protected bone health and reduced metabolic disturbances. Furthermore, in a clinical study, all menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, vertigo, fatigue, rheumatic pain, palpitations, formication, and headache, as well as colpoxerosis, were significantly improved by taking MS-10 for 90 days. Therefore, the evidence supports that MS-10 is an effective natural substance that can safely improve menopausal symptoms, including colpoxerosis.
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