Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infectionopen access
- Authors
- Kang, Chang Kyung; Shin, Hyun Mu; Choe, Pyoeng Gyun; Park, Jiyoung; Hong, Jisu; Seo, Jung Seon; Lee, Yung Hie; Chang, Euijin; Kim, Nam Joong; Kim, Minji; Kim, Yong-Woo; Kim, Hang-Rae; Lee, Chang-Han; Seo, Jun-Young; Park, Wan Beom; Oh, Myoung-Don
- Issue Date
- May-2022
- Publisher
- BMC
- Keywords
- SARS-CoV-2; COVID-19; Vaccination; Immune response; mRNA
- Citation
- BMC MEDICINE, v.20, no.1
- Journal Title
- BMC MEDICINE
- Volume
- 20
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71877
- DOI
- 10.1186/s12916-022-02383-4
- ISSN
- 1741-7015
- Abstract
- Background Practical guidance is needed regarding the vaccination of coronavirus disease 2019 (COVID-19) convalescent individuals in resource-limited countries. It includes the number of vaccine doses that should be given to unvaccinated patients who experienced COVID-19 early in the pandemic. Methods We recruited COVID-19 convalescent individuals who received one or two doses of an mRNA vaccine within 6 or around 18 months after a diagnosis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Their samples were assessed for IgG-binding or neutralizing activity and cell-mediated immune responses against SARS-CoV-2 wild-type and variants of concern. Results A total of 43 COVID-19 convalescent individuals were analyzed in the present study. The results showed that humoral and cellular immune responses against SARS-CoV-2 wild-type and variants of concern, including the Omicron variant, were comparable among patients vaccinated within 6 versus around 18 months. A second dose of vaccine did not significantly increase immune responses. Conclusion One dose of mRNA vaccine should be considered sufficient to elicit a broad immune response even around 18 months after a COVID-19 diagnosis.
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