Local Drug Delivery Strategies for Glioblastoma Treatment
- Authors
- 차기두; 정손우; 최승홍; 김대형
- Issue Date
- Jul-2022
- Publisher
- 대한뇌종양학회
- Keywords
- Drug administration routes; Chemotherapy; Blood-brain barrier; Brain tumor; Absorbable implants; Drug delivery systems.
- Citation
- Brain Tumor Research and Treatment, v.10, no.3, pp 151 - 157
- Pages
- 7
- Journal Title
- Brain Tumor Research and Treatment
- Volume
- 10
- Number
- 3
- Start Page
- 151
- End Page
- 157
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72056
- ISSN
- 2288-2405
2288-2413
- Abstract
- Glioblastoma multiforme (GBM) is a brain tumor notorious for its malignancy. The key reason for the lim- ited efficacy of standard treatment is the high recurrence rate of GBM, even after surgical resection. Hence, intensive postsurgical chemical therapies, such as the systemic delivery of various drugs and/ or drug combinations, are typically followed after surgery. However, overcoming the blood-brain barrier by systemic administration to efficiently deliver drugs to the brain tumor remains a daunting goal. There- fore, various local drug delivery methods showing potential for improved therapeutic efficacy have been proposed. In particular, the recent application of electronic devices for the controlled delivery of che- motherapy drugs to GBM tissue has attracted attention. We herein review the recent progress of local drug delivery strategies, including electronics-assisted strategies, at the research and commercial level. We also present a brief discussion of the unsolved challenges and future research direction of localized chemotherapy methods for GBM.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72056)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.