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Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry

Authors
Park, So YoungLee, Sang MinShin, Jong WookChoi, Byoung WhuiKim, HojoongLee, Jae SeungLee, Sang DoPark, Sung SooMoon, Hwa SikPark, Yong Bum
Issue Date
Mar-2016
Publisher
KOREAN ASSOC INTERNAL MEDICINE
Keywords
Hypertension; pulmonary; Thromboembolism; Epidemiologic studies; Characteristics
Citation
KOREAN JOURNAL OF INTERNAL MEDICINE, v.31, no.2, pp 305 - 312
Pages
8
Journal Title
KOREAN JOURNAL OF INTERNAL MEDICINE
Volume
31
Number
2
Start Page
305
End Page
312
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7208
DOI
10.3904/kjim.2014.122
ISSN
1226-3303
2005-6648
Abstract
Background/Aims: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and outcomes of CTEPH in a Korean cohort. Methods: This study included South Korean patients diagnosed with CTEPH between September 2008 and October 2011. Baseline characteristics, treatments and outcomes were analyzed. Results: A total of 134 patients were included in this study with 76 females (56.7%). Their median age was 58.3 +/- 15.9 years and dyspnea (112 patients, 83.5%) was the most common presenting symptom. Sixty-three patients (47%) had a history of acute pulmonary embolism or deep vein thrombosis, and six (4.5%) had pulmonary tuberculosis. In total, 28 patients (21%) underwent pulmonary thromboendarterectomy (PTE), and 99 patients had medical therapy. During the study period, 18 patients (13.4%) died. In a multivariate analysis, higher hemoglobin (relative risk [RR], 1.516; 95% confidence interval [CI], 1.053 to 2.184; p = 0.025) and lower total cholesterol levels (RR, 0.982; 95% CI, 0.965 to 0.999; p = 0.037) were associated with increased mortality. Conclusions: This was the first national cohort study of Korean patients with CTEPH. Accurate diagnosis, characterization and distributions of CTEPH are imperative for prompt treatment in patients, particularly those undergoing PTE.
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