Cutting Edge: Progesterone Directly Upregulates Vitamin D Receptor Gene Expression for Efficient Regulation of T Cells by Calcitriol
DC Field | Value | Language |
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dc.contributor.author | Thangamani, Shankar | - |
dc.contributor.author | Kim, Myughoo | - |
dc.contributor.author | Son, Youngmin | - |
dc.contributor.author | Huang, Xinxin | - |
dc.contributor.author | Kim, Heejoo | - |
dc.contributor.author | Lee, Jee H. | - |
dc.contributor.author | Cho, Jungyoon | - |
dc.contributor.author | Ulrich, Benjamin | - |
dc.contributor.author | Broxmeyer, Hal E. | - |
dc.contributor.author | Kim, Chang H. | - |
dc.date.accessioned | 2024-02-19T02:30:35Z | - |
dc.date.available | 2024-02-19T02:30:35Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.issn | 1550-6606 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72110 | - |
dc.description.abstract | The two nuclear hormone receptor ligands progesterone and vitamin D (vit.D) play important roles in regulating T cells. The mechanism that connects these two hormones in regulating T cells has not been established. In this study, we report that progesterone is a novel inducer of vit.D receptor (VDR) in T cells and makes T cells highly sensitive to calcitriol. At the molecular level, the induction by progesterone is mediated by two progesterone receptor-binding elements in the intron region after the first noncoding exon of the human VDR gene. Increased expression of VDR by progesterone allows highly sensitive regulation of T cells by vit.D even when vit.D levels are suboptimal. This novel regulatory pathway allows enhanced induction of regulatory T cells but suppression of Th1 and Th17 cells by the two nuclear hormones. The results have significant ramifications in effective regulation of T cells to prevent adverse immune responses during pregnancy. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | Cutting Edge: Progesterone Directly Upregulates Vitamin D Receptor Gene Expression for Efficient Regulation of T Cells by Calcitriol | - |
dc.type | Article | - |
dc.identifier.doi | 10.4049/jimmunol.1401923 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.194, no.3, pp 883 - 886 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000348134000008 | - |
dc.identifier.scopusid | 2-s2.0-84921494821 | - |
dc.citation.endPage | 886 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 883 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 194 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | D-3 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | SUPPRESSES | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | PREGNANCY | - |
dc.subject.keywordPlus | EXPANSION | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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