Cutting Edge: Progesterone Directly Upregulates Vitamin D Receptor Gene Expression for Efficient Regulation of T Cells by Calcitriol
- Authors
- Thangamani, Shankar; Kim, Myughoo; Son, Youngmin; Huang, Xinxin; Kim, Heejoo; Lee, Jee H.; Cho, Jungyoon; Ulrich, Benjamin; Broxmeyer, Hal E.; Kim, Chang H.
- Issue Date
- Feb-2015
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Citation
- JOURNAL OF IMMUNOLOGY, v.194, no.3, pp 883 - 886
- Pages
- 4
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Volume
- 194
- Number
- 3
- Start Page
- 883
- End Page
- 886
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72110
- DOI
- 10.4049/jimmunol.1401923
- ISSN
- 0022-1767
1550-6606
- Abstract
- The two nuclear hormone receptor ligands progesterone and vitamin D (vit.D) play important roles in regulating T cells. The mechanism that connects these two hormones in regulating T cells has not been established. In this study, we report that progesterone is a novel inducer of vit.D receptor (VDR) in T cells and makes T cells highly sensitive to calcitriol. At the molecular level, the induction by progesterone is mediated by two progesterone receptor-binding elements in the intron region after the first noncoding exon of the human VDR gene. Increased expression of VDR by progesterone allows highly sensitive regulation of T cells by vit.D even when vit.D levels are suboptimal. This novel regulatory pathway allows enhanced induction of regulatory T cells but suppression of Th1 and Th17 cells by the two nuclear hormones. The results have significant ramifications in effective regulation of T cells to prevent adverse immune responses during pregnancy.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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