Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus
- Authors
- Son, Young Min; Ahn, Sung Min; Jang, Mi Seon; Moon, Yang Soo; Kim, Sang Hoon; Cho, Kwang-Kedn; Han, Seung Hyun; Yun, Cheol-Heui
- Issue Date
- Nov-2008
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Resistin; Lipoteichoic acid; Staphylococcus aureus; Dendritic cells; T cells; Interferon-gamma; Interleukin-4; Obesity
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.376, no.3, pp 599 - 604
- Pages
- 6
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 376
- Number
- 3
- Start Page
- 599
- End Page
- 604
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72142
- DOI
- 10.1016/j.bbrc.2008.09.037
- ISSN
- 0006-291X
1090-2104
- Abstract
- Resistin is an adipokine whose physiologic role in obesity, type 11 diabetes mellitus, and inflammatory diseases has been a subject of debate because while it is expressed in adipocytes and adipose tissue in mouse, it is expressed in leukocytes, such as macrophages, in human. In the present study, we attempt to define the effect of resistin oil human dendritic cells (DCs) derived from CD14* monocytes. When DCs were Stimulated with lipoteichoic acid (LTA) and treated with various concentrations of resistin, antigen-Uptake process and the endocytic capacity of DCs were decreased. It is intriguing that resistin attenuated cytokine production in LTA-primed DCs. Consequently, T cell activity was reduced when lymphocytes were mixed with Staphylococcus aureus-primed autologous DCs treated with resistin compared to S. aureus-primed DCs without resistin. Our results suggest that resistin interferes with the efficacy of immune responses activated by Gram-positive bacterial infection in human DCs. (C) 2008 Elsevier Inc. All rights reserved.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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