Addressing of LnCaP Cell Using Magnetic Particles Assisted Impedimetric Microelectrode
- Authors
- Dung Thi Xuan Nguyen; Trong Binh Tran; Phuong-Diem Nguyen; Min, Junhong
- Issue Date
- Mar-2016
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Patterning; Metastatic Prostate Tumor Cell; Proliferation; Biocompatible; Magnetic Particle; Interdigitated; Impedance Sensing
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.16, no.3, pp 2933 - 2936
- Pages
- 4
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 16
- Number
- 3
- Start Page
- 2933
- End Page
- 2936
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7237
- DOI
- 10.1166/jnn.2016.11094
- ISSN
- 1533-4880
1533-4899
- Abstract
- In this study, we provide a facile, effective technique for a simple isolation and enrichment of low metastatic prostate tumor cell LNCaP using biocompatible, magnetic particles asissted impedimetric sensing system. Hydrophobic cell membrane anchors (BAM) were generated onto magnetic particles which diameters vary from 50 nm to 5 mu m and were used to capture LNCaP cells from the suspension. Finally, magnetic particle-LNCaP complex were addressed onto the surface of the interdigitated microelectrode (IDM). Cell viability was monitored by our laboratory developed-technique Electrical Cell Substrate Impedance Sensing (ECIS). The results reavealed that 50 nm-magnetic particles showed best performance in terms of cell separation and cell viability. This technique provides a simple and efficient method for the direct addressing of LNCaP cell on the surface and enhances better understanding of cell behavior for cancer management in the near future.
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