Chlorpropham, a carbamate ester herbicide, has an endocrine-disrupting potential by inhibiting the homodimerization of human androgen receptor
DC Field | Value | Language |
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dc.contributor.author | Jeong, D.-H. | - |
dc.contributor.author | Jung, D.-W. | - |
dc.contributor.author | Jang, C.-H. | - |
dc.contributor.author | Kim, U.-J. | - |
dc.contributor.author | Park, Y. | - |
dc.contributor.author | Park, Y. | - |
dc.contributor.author | Lee, H.-S. | - |
dc.date.accessioned | 2024-02-29T01:00:35Z | - |
dc.date.available | 2024-02-29T01:00:35Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 0269-7491 | - |
dc.identifier.issn | 1873-6424 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72564 | - |
dc.description.abstract | This study was carried out to provide the evidence with respect to the adverse potential of chlorpropham, a representative carbamate ester herbicide product, on the endocrine system by using in vitro testing methods in accordance with the Organization for Economic Cooperation and Development Test Guideline No. 458 (22Rv1/MMTV_GR-KO human androgen receptor [AR] transcriptional activation assay) and a bioluminescence resonance energy transfer-based AR homodimerization assay. Results revealed that chlorpropham had no AR agonistic effects, but it was determined to be a true AR antagonist without intrinsic toxicity against the applied cell lines. In the mechanism of chlorpropham-induced AR-mediated adverse effects, chlorpropham suppressed cytoplasmic AR translocation to the nucleus by inhibiting the homodimerization of the activated ARs. This suggests that chlorpropham exposure caused endocrine-disrupting effects through its interactions with human AR. Additionally, this study might help identify the genomic pathway of the AR-mediated endocrine-disrupting potential of N-phenyl carbamate herbicides. © 2023 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Chlorpropham, a carbamate ester herbicide, has an endocrine-disrupting potential by inhibiting the homodimerization of human androgen receptor | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.envpol.2023.121437 | - |
dc.identifier.bibliographicCitation | Environmental Pollution, v.325 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000959850400001 | - |
dc.identifier.scopusid | 2-s2.0-85151477126 | - |
dc.citation.title | Environmental Pollution | - |
dc.citation.volume | 325 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Androgen receptor | - |
dc.subject.keywordAuthor | Chlorpropham | - |
dc.subject.keywordAuthor | Endocrine-disrupting potential | - |
dc.subject.keywordAuthor | Genomic pathway | - |
dc.subject.keywordPlus | PESTICIDES | - |
dc.subject.keywordPlus | CHEMICALS | - |
dc.subject.keywordPlus | POTATOES | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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