Chlorpropham, a carbamate ester herbicide, has an endocrine-disrupting potential by inhibiting the homodimerization of human androgen receptor
- Authors
- Jeong, D.-H.; Jung, D.-W.; Jang, C.-H.; Kim, U.-J.; Park, Y.; Park, Y.; Lee, H.-S.
- Issue Date
- May-2023
- Publisher
- Elsevier Ltd
- Keywords
- Androgen receptor; Chlorpropham; Endocrine-disrupting potential; Genomic pathway
- Citation
- Environmental Pollution, v.325
- Journal Title
- Environmental Pollution
- Volume
- 325
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72564
- DOI
- 10.1016/j.envpol.2023.121437
- ISSN
- 0269-7491
1873-6424
- Abstract
- This study was carried out to provide the evidence with respect to the adverse potential of chlorpropham, a representative carbamate ester herbicide product, on the endocrine system by using in vitro testing methods in accordance with the Organization for Economic Cooperation and Development Test Guideline No. 458 (22Rv1/MMTV_GR-KO human androgen receptor [AR] transcriptional activation assay) and a bioluminescence resonance energy transfer-based AR homodimerization assay. Results revealed that chlorpropham had no AR agonistic effects, but it was determined to be a true AR antagonist without intrinsic toxicity against the applied cell lines. In the mechanism of chlorpropham-induced AR-mediated adverse effects, chlorpropham suppressed cytoplasmic AR translocation to the nucleus by inhibiting the homodimerization of the activated ARs. This suggests that chlorpropham exposure caused endocrine-disrupting effects through its interactions with human AR. Additionally, this study might help identify the genomic pathway of the AR-mediated endocrine-disrupting potential of N-phenyl carbamate herbicides. © 2023 Elsevier Ltd
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