Azole pesticide products and their hepatic metabolites cause endocrine disrupting potential by suppressing the homo-dimerization of human estrogen receptor alpha
- Authors
- Jung, D.-W.; Jeong, D.-H.; Lee, H.-S.
- Issue Date
- Feb-2023
- Publisher
- Elsevier Ltd
- Keywords
- Antagonist; Azole; Dimerization; Estrogen receptor alpha; OECD test Guideline
- Citation
- Environmental Pollution, v.318
- Journal Title
- Environmental Pollution
- Volume
- 318
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72565
- DOI
- 10.1016/j.envpol.2022.120894
- ISSN
- 0269-7491
1873-6424
- Abstract
- We selected azole pesticides products that are managed by setting maximum residue limits (MRLs) in the Republic of Korea and describe the estrogen receptor (ER) α-related negative effect to endocrine system using in vitro Organization for Economic Cooperation and Development performance-based test guideline. No azoles were found to be an ERα agonist. Conversely, three azoles (bitertanol, cafenstrole, and tebufenpyrad) were determined to be ERα antagonists. In addition, the ERα antagonistic activities of bitertanol, cafenstrole, and tebufenpyrad were not significantly perturbed in the existence of phase I (hydroxylation, dealkylation, oxidation or reduction) and phase II (conjugation). Regarding the mechanism underlying their ERα-mediated endocrine disrupting potentials, ERα proteins cannot be translocated to the nucleus by suppressing the dimerization of ERα in the cytoplasm by bitertanol, cafenstrole, and tebufenpyrad. These data indicated that azole pesticide products show the capability to interfere the ERα-related human endocrine system. Furthermore, we identified the mechanism of ERα-mediated endocrine disrupting by azole insecticide products through this study. © 2022 Elsevier Ltd
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