Rational design of niobium carbide MXene quantum dots decorated with arginine for the fluorescence sensing of superoxide anion in Saccharomyces cerevisiae cells
- Authors
- Joshi, Dharaben J.; Jha, Sanjay; Malek, Naved I.; Park, Tae Jung; Kailasa, Suresh Kumar
- Issue Date
- Apr-2024
- Publisher
- Elsevier B.V.
- Keywords
- Arginine-Nb2C MQDs; Cell imaging; Cytotoxicity; Fluorescence quenching; Superoxide anion
- Citation
- Sensors and Actuators B: Chemical, v.404
- Journal Title
- Sensors and Actuators B: Chemical
- Volume
- 404
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72702
- DOI
- 10.1016/j.snb.2023.135226
- ISSN
- 0925-4005
0925-4005
- Abstract
- In this work, arginine functionalized niobium carbide MXene quantum dots (arginine-Nb2C MQDs) were synthesized using Nb2AlC, NaOH and arginine as reagents. The as-synthesized probe showed bluish-green fluorescence under UV light at 365 nm. The structural and morphological changes of as-synthesized arginine-Nb2C MQDs were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR), Raman spectroscopy and high-resolution transmittance electron microscopy (HR-TEM). The synthesized fluorescent arginine-Nb2C MQDs were stable, with an average size of 1.92 ± 0.52 nm. As-synthesized arginine-Nb2C MQDs act as a sensor for detecting superoxide anion (O2•−) via a fluorescence “turn-off” mechanism with the detection limit of 31.89 nM. The fluorescence of arginine-Nb2C MQDs is quenched by O2•− via dynamic fluorescence quenching mechanism. Fascinatingly, the synthesized arginine-Nb2C MQDs showed negligible cytotoxicity on HeLa cells and acted as promising candidates for sensing of O2•− in Saccharomyces cerevisiae cells. © 2024 Elsevier B.V.
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