Anti-Inflammatory Effects of the LK5 Herbal Complex on LPS- and IL-4/IL-13-Stimulated HaCaT Cells and a DNCB-Induced Animal Model of Atopic Dermatitis in BALB/c Mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun-Jeong | - |
dc.contributor.author | Kim, So-Yeon | - |
dc.contributor.author | Bae, Ho Jung | - |
dc.contributor.author | Choi, Yu-Yeong | - |
dc.contributor.author | An, Ju-Yeon | - |
dc.contributor.author | Cho, Ye Eun | - |
dc.contributor.author | Cho, So-Young | - |
dc.contributor.author | Lee, Su-Jung | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.contributor.author | Sin, MinSub | - |
dc.contributor.author | Yun, Young Min | - |
dc.contributor.author | Lee, Jong Ryul | - |
dc.contributor.author | Park, Se Jin | - |
dc.date.accessioned | 2024-03-13T05:00:22Z | - |
dc.date.available | 2024-03-13T05:00:22Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72804 | - |
dc.description.abstract | Atopic dermatitis (AD) is a chronic inflammatory skin disease influenced by a complex interplay of genetic and environmental factors. The activation of the JAK-STAT pathway increases the expression of inflammatory cytokines such as IL-4 and IL-13, further deteriorating AD. Therefore, for the treatment of AD, the JAK-STAT pathway is emerging as a significant target, alongside inflammatory cytokines. This study investigates the potential therapeutic effects of a novel herbal complex, LK5, composed of Scutellaria baicalensis, Liriope platyphylla, Sophora flavescens, Dictammus dasycarpus, and Phellodendron schneider, known for their anti-inflammatory and immune-modulating properties. We examined the anti-inflammatory and anti-AD effects of the LK5 herbal complex in HaCaT cells stimulated by LPS and IL-4/IL-13, as well as in a mouse model of AD induced by DNCB. In HaCaT cells stimulated with LPS or IL-4/IL-13, the LK5 herbal complex demonstrated anti-inflammatory effects by inhibiting the expression of inflammatory cytokines including TNF-α, IL-6, and IL-1β, and downregulating the phosphorylation of STAT proteins. In a murine AD-like model induced by DNCB, administration of the LK5 herbal complex significantly ameliorated clinical symptoms, including dermatitis, ear thickness, and TEWL. Histological analysis revealed a reduction in epidermal thickness and mast cell infiltration. The LK5 herbal complex also inhibited pruritus induced by compound 48/80. Furthermore, the LK5 herbal complex treatment significantly decreased the levels of inflammatory cytokines such as TSLP, IL-6, and IgE in plasma and ear tissue of AD-induced mice. These findings suggest that the LK5 herbal complex may modulate the immune response and alleviate AD symptoms by inhibiting STAT pathways. © 2023 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Anti-Inflammatory Effects of the LK5 Herbal Complex on LPS- and IL-4/IL-13-Stimulated HaCaT Cells and a DNCB-Induced Animal Model of Atopic Dermatitis in BALB/c Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/pharmaceutics16010040 | - |
dc.identifier.bibliographicCitation | Pharmaceutics, v.16, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001151307800001 | - |
dc.identifier.scopusid | 2-s2.0-85183130040 | - |
dc.citation.number | 1 | - |
dc.citation.title | Pharmaceutics | - |
dc.citation.volume | 16 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.subject.keywordAuthor | itching | - |
dc.subject.keywordAuthor | LK5 herbal complex | - |
dc.subject.keywordAuthor | signal transducers and activators of transcription | - |
dc.subject.keywordPlus | 48/80-INDUCED SCRATCHING BEHAVIOR | - |
dc.subject.keywordPlus | ITCH-RELATED RESPONSES | - |
dc.subject.keywordPlus | SCUTELLARIA-BAICALENSIS | - |
dc.subject.keywordPlus | LIRIOPE-PLATYPHYLLA | - |
dc.subject.keywordPlus | SOPHORA-FLAVESCENS | - |
dc.subject.keywordPlus | CHLOROGENIC ACID | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | BARRIER | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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