Persistent B Cell–Derived MHC Class II Signaling Is Required for the Optimal Maintenance of Tissue-Resident Helper T Cellsopen access
- Authors
- Son, Young Min; Cheon, In Su; Li, Chaofan; Sun, Jie
- Issue Date
- Feb-2024
- Publisher
- American Association of Immunologists
- Citation
- ImmunoHorizons, v.8, no.2, pp 163 - 171
- Pages
- 9
- Journal Title
- ImmunoHorizons
- Volume
- 8
- Number
- 2
- Start Page
- 163
- End Page
- 171
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72955
- DOI
- 10.4049/immunohorizons.2300093
- ISSN
- 2573-7732
- Abstract
- Emerging studies have identified the critical roles of tissue-resident memory CD8+ T (TRM) and B (BRM) cells in the protection against mucosal viral infections, but the underlying mechanisms regulating robust development of TRM and BRM cells remain incompletely understood. We have recently shown that tissue-resident helper CD4+ T (TRH) cells, developed following influenza virus infection, function to sustain the optimal maintenance of TRM and BRM cells at the mucosal surface. In this study, we have explored the cellular and molecular cues modulating lung TRH persistence after influenza infection in C57BL/6 mice. We found that TRH cells were colocalized in tertiary lymphoid structures (TLSs) with local B cells. Abolishing TLSs or the depletion of B cells impaired lung TRH cell numbers. Of note, we found that persistent TCR signaling is needed for the maintenance of TRH cells after the clearance of infectious influenza virus. Furthermore, selective ablation of B cell–derived MHC class II resulted in partial reduction of lung TRH cell number after influenza infection. Our findings suggest that the interaction between lung-resident TRH cells and B cells, along with persistent Ag stimulation, is required to maintain TRH cells after respiratory viral infection. Copyright © 2024 The Authors.
- Files in This Item
-
- Appears in
Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72955)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.