The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot studyopen access
- Authors
- Choi, Sun Young; Koh, Young Gue; Roh, Yoon Jin; Park, Kui Young
- Issue Date
- Apr-2024
- Publisher
- WILEY
- Keywords
- enoxolone; erythema; laser therapy
- Citation
- JOURNAL OF COSMETIC DERMATOLOGY
- Journal Title
- JOURNAL OF COSMETIC DERMATOLOGY
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73551
- DOI
- 10.1111/jocd.16329
- ISSN
- 1473-2130
1473-2165
- Abstract
- BackgroundEnoxolone, derived from licorice, possesses potent anti-inflammatory, and antioxidant properties. However, its effectiveness in alleviating post-laser reactions has not been extensively studied.AimsThis randomized split-face pilot study aimed to evaluate the effects of enoxolone on skin following laser treatment.Patients/MethodsTen healthy subjects underwent non-ablative 1550 nm Er:Glass fractional laser treatment and then randomly applied a moisturizer without enoxolone on one side of the face and a dermo-cosmetic formular containing 2% enoxolone mixed with the same moisturizer on the other side. The erythema index (EI), clinician's erythema assessment (CEA), and pain scores were recorded at 30 min, 60 min, and 24 h posttreatment.ResultsThe group treated with enoxolone showed significantly lower EI and CEA compared to the control group at 24 h posttreatment. Additionally, pain scores were notably reduced in the enoxolone-treated group 30 min after treatment.ConclusionsThis study suggests that dermo-cosmetic formular containing 2% enoxolone is effective in reducing erythema and pain following laser treatment.
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