Apoptotic events induced by prototype foamy virus infection
- Authors
- Kim, Jinsun; Hamid, Faysal Bin; Shin, Cha-Gyun
- Issue Date
- Jan-2016
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Prototype foamy virus; apoptosis; caspase-3
- Citation
- ANIMAL CELLS AND SYSTEMS, v.20, no.1, pp 15 - 23
- Pages
- 9
- Journal Title
- ANIMAL CELLS AND SYSTEMS
- Volume
- 20
- Number
- 1
- Start Page
- 15
- End Page
- 23
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7387
- DOI
- 10.1080/19768354.2015.1137488
- ISSN
- 1976-8354
2151-2485
- Abstract
- Foamy virus infection induces cytopathology in several cell types from different species. But the exact mechanism is still unknown. In this study, we have investigated the mechanism of cell death induced by prototype foamy virus (PFV) infection in baby hamster kidney (BHK 21) cell lines. PFV induces apoptosis by exhibiting morphological alterations such as chromatin condensation, blebbing, and nuclear fragmentation. In addition, PFV infection causes chromosomal DNA fragmentation, up-regulation of Bax, and activation of caspase-3, but not caspase-8. Up-regulation of Bax initiates the translocation of cytochrome-c from mitochondria to the cytoplasm, suggesting predominantly to the mitochondrial-mediated pathway. Blocking apoptosis using caspase inhibitors increased PFV-infected BHK 21 cell viability. Although blocking apoptosis resulted in reduced progeny release, maximal accumulation of PFV was found in apoptosis-blocked cells. This report provides the first experimental evidence of apoptosis induced by PFV infection, which will provide valuable insights for foamy viral pathology.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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