Positive Results from the Fecal Immunochemical Test Can Be Related to Dementia: A Nationwide Population-Based Study in South Korea
- Authors
- Jun, Y.K.; Lee, S.W.; Kim, K.W.; Moon, J.M.; Koh, S.-J.; Lee, H.J.; Kim, J.S.; Han, K.; Im, J.P.
- Issue Date
- Feb-2023
- Publisher
- NLM (Medline)
- Keywords
- Alzheimer’s disease; dementia; occult blood; population surveillance; vascular dementia
- Citation
- Journal of Alzheimer's disease : JAD, v.91, no.4, pp 1515 - 1525
- Pages
- 11
- Journal Title
- Journal of Alzheimer's disease : JAD
- Volume
- 91
- Number
- 4
- Start Page
- 1515
- End Page
- 1525
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73918
- DOI
- 10.3233/JAD-220770
- ISSN
- 1387-2877
1875-8908
- Abstract
- BACKGROUND: The fecal immunochemical test (FIT) is widely used in screening for colorectal cancer (CRC), but FIT results can be positive for diseases other than CRC. OBJECTIVE: We investigated the association between positive results of FIT and the incidence of dementia using a nationwide database. METHODS: FIT-positive participants were collected from a database provided by the Korean National Health Insurance Service. RESULTS: The incidence of all kinds of dementia was higher in FIT-positive than FIT-negative subjects (p < 0.0001). FIT-positive participants had a higher risk of Alzheimer's disease (AD) (p < 0.0001) and vascular dementia (p = 0.0002), compared to participants with FIT negativity. The risk of all kinds of dementia or AD in FIT-positive participants was higher in younger (age < 65 years) than older participants (p < 0.0001 for all kinds of dementia; p = 0.0002 for AD). CONCLUSION: FIT positivity was correlated with an increased risk of dementia, especially in participants under 65 years of age. The study suggests that clinicians can consider dementia when FIT-positive participants fail to show any malignancies.
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