Preadipocytes potentiate melanoma progression and M2 macrophage polarization in the tumor microenvironment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Tae Jin | - |
dc.contributor.author | Kim, Ok-Hyeon | - |
dc.contributor.author | Kang, Hana | - |
dc.contributor.author | Lee, Hyun Jung | - |
dc.date.accessioned | 2024-06-17T01:30:41Z | - |
dc.date.available | 2024-06-17T01:30:41Z | - |
dc.date.issued | 2024-08 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74213 | - |
dc.description.abstract | Melanoma, the deadliest skin cancer, originates from epidermal melanocytes. The influence of preadipocytes on melanoma is less understood. We co-cultured mouse melanoma B16 cells with 3T3L1 preadipocytes to form mixed spheroids and observed increased melanoma proliferation and growth compared to B16-only spheroids. Metastasis-related proteins YAP, TAZ, and PD-L1 levels were also higher in mixed spheroids. Treatment with exosome inhibitor GW4869 halted melanoma growth and reduced expression of these proteins, suggesting exosomal crosstalk between B16 and 3T3L1 cells. MiR-155 expression was significantly higher in mixed spheroids, and GW4869 reduced its levels. Additionally, co-culturing with Raw264.7 macrophage cells increased M2 markers IL-4 and CD206 in Raw264.7 cells, effects that were diminished by GW4869. These results indicate that preadipocytes may enhance melanoma progression and metastasis via exosomal interactions. © 2024 Elsevier Inc. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Preadipocytes potentiate melanoma progression and M2 macrophage polarization in the tumor microenvironment | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2024.150129 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, v.721 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001244153700001 | - |
dc.identifier.scopusid | 2-s2.0-85193214504 | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.volume | 721 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Melanoma | - |
dc.subject.keywordAuthor | miR-155 | - |
dc.subject.keywordAuthor | Preadipocytes | - |
dc.subject.keywordAuthor | Tumor microenvironment | - |
dc.subject.keywordPlus | CANCER EXOSOMES | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | MICRORNAS | - |
dc.subject.keywordPlus | MIR-155 | - |
dc.subject.keywordPlus | NICHE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.