Association of non-alcoholic fatty liver disease with incident dementia later in life among elder adultsopen access
- Authors
- Jeong, Seogsong; Oh, Yun Hwan; Choi, Seulggie; Chang, Jooyoung; Kim, Sung Min; Son, Joung Sik; Lee, Gyeongsil; Ahn, Joseph C; Lee, Dong Hyeon; Koo, Bo Kyung; Kim, Won; Park, Sang Min
- Issue Date
- Jul-2022
- Publisher
- 대한간학회
- Keywords
- Non-alcoholic fatty liver disease; Epidemiology; Alzheimer disease; Vascular dementia
- Citation
- Clinical and Molecular Hepatology, v.28, no.3, pp 510 - 521
- Pages
- 12
- Journal Title
- Clinical and Molecular Hepatology
- Volume
- 28
- Number
- 3
- Start Page
- 510
- End Page
- 521
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74398
- DOI
- 10.3350/cmh.2021.0332
- ISSN
- 2287-2728
2287-285X
- Abstract
- Background/Aims: Accumulating evidence suggests a link between non-alcoholic fatty liver disease (NAFLD) and brain health. However, population-based evidence on the association between NAFLD and dementia remains unclear. This study was conducted to determine the association between NAFLD and incident dementia.Methods: The study population included 608,994 adults aged ≥60 years who underwent health examinations between 2009 and 2010. Data were collected from the Korean National Health Insurance Service database. NAFLD was assessed using the fatty liver index (FLI). A Cox proportional hazards regression model was used to determine the association between NAFLD and dementia.Results: During the 6,495,352 person-years of follow-up, 48,538 participants (8.0%) developed incident dementia. The participants were classified into low (FLI <30), intermediate (FLI ≥30 and <60), and high (FLI ≥60) groups. In the overall study population, the FLI groups were associated with a risk of dementia (P for trend <0.001). After propensity score matching, a low FLI was associated with a reduced risk of dementia (adjusted hazard ration [aHR], 0.96; 95% confidence interval [CI], 0.93–0.98; P=0.002), whereas a high FLI (NAFLD) was associated with an increased risk of dementia (aHR, 1.05; 95% CI, 1.02–1.08; P=0.001). A higher risk of dementia in the high FLI group than in the intermediate FLI group was attributed to Alzheimer’s disease (aHR, 1.04; 95% CI, 1.01–1.07; P=0.004) rather than vascular dementia (aHR, 0.94; 95% CI, 0.75–1.18; P=0.602).Conclusions: NAFLD was associated with an increased risk of dementia, which was attributed to an increased risk of Alzheimer’s disease.
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