Predicting factor analysis of postoperative complications after robot-assisted radical cystectomy: Multicenter KORARC database study
- Authors
- Kim, Hwanik; Jeong, Byong Chang; Lee, Sangchul; Ku, Ja Hyeon; Kwon, Tae Gyun; Kim, Tae-Hwan; Jeon, Seung Hyun; Lee, Sang Hyub; Nam, Jong Kil; Kim, Wansuk; Lee, Ji Youl; Hong, Sung Hoo; Rha, Koon Ho; Han, Woong Kyu; Ham, Won Sik; Lee, Young Goo; Lee, Yong Seong; Park, Sung Yul; Yoon, Young Eun; Kang, Sung Gu; Kang, Seok Ho; Oh, Jong Jin
- Issue Date
- Sep-2022
- Publisher
- WILEY
- Keywords
- bladder cancer; minimally invasive surgical procedures; postoperative complications; radical cystectomy; robotic surgical procedures
- Citation
- INTERNATIONAL JOURNAL OF UROLOGY, v.29, no.9, pp 939 - 946
- Pages
- 8
- Journal Title
- INTERNATIONAL JOURNAL OF UROLOGY
- Volume
- 29
- Number
- 9
- Start Page
- 939
- End Page
- 946
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74457
- DOI
- 10.1111/iju.14815
- ISSN
- 0919-8172
1442-2042
- Abstract
- Objectives To evaluate postoperative complications following robot-assisted radical cystectomy in patients diagnosed with bladder cancer and reveal if there are predictors for postoperative complications. Methods Prospectively collected medical records of 730 robot-assisted radical cystectomy patients between 2007/04 and 2019/05 in 13 tertiary referral centers were reviewed. Perioperative outcomes were compared between two groups by postoperative complications (complication vs non-complication). We assessed recurrence-free survival, cancer-specific survival, and overall survival between groups. Regression analyses were implemented to identify factors associated with postoperative complications. Results Any total and high-grade complication (Clavien-Dindo grade >= 3) rates were 57.8% and 21.1%, respectively. Patients in complication group had significantly higher proportion of diabetes mellitus (P = 0.048), chronic kidney disease (P = 0.011), dyslipidemia (P < 0.001), longer operation time (P = 0.001), more estimated blood loss (P = 0.001), and larger intraoperative fluid volume (P < 0.001). There was a significant difference in cancer-specific survival (log-rank P = 0.038, median cancer-specific survival: both groups not reached). Dyslipidemia (odds ratio 2.59, P = 0.002) and intraoperative fluid volume (odds ratio 1.0002, P = 0.040) were significantly associated with high-grade postoperative complications. Diabetes mellitus (odds ratio 1.97, P = 0.028), chronic kidney disease (odds ratio 1.89, P = 0.046), dyslipidemia (odds ratio 5.94, P = 0.007), and intraoperative fluid volume (odds ratio 1.0002, P = 0.009) were significantly associated with any postoperative complications. Conclusions Patients with diabetes mellitus, chronic kidney disease, dyslipidemia, or a relatively large intraoperatively infused fluid volume are more likely to develop postoperative complications. Patients with postoperative complications might have a possibility of lower cancer-specific survival rate.
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