Preoperative smoking and robot-assisted radical cystectomy outcomes & complications in multicenter KORARC databaseopen access
- Authors
- Choi, Joongwon; Lee, Jooyoung; Hwang, Yu Been; Jeong, Byong Chang; Lee, Sangchul; Ku, Ja Hyeon; Nam, Jong Kil; Kim, Wansuk; Lee, Ji Youl; Hong, Sung Hoo; Rha, Koon Ho; Han, Woong Kyu; Ham, Won Sik; Kang, Sung Gu; Kang, Seok Ho; Oh, Jong Jin; Lee, Young Goo; Kwon, Tae Gyun; Kim, Tae-Hwan; Jeon, Seung Hyun; Lee, Sang Hyub; Park, Sung Yul; Yoon, Young Eun; Lee, Yong Seong
- Issue Date
- May-2024
- Publisher
- Nature Research
- Keywords
- Bladder cancer; Cystectomy; Robot-assisted surgery; Smoking; Survival analysis
- Citation
- Scientific reports, v.14, no.1
- Journal Title
- Scientific reports
- Volume
- 14
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74460
- DOI
- 10.1038/s41598-024-61005-6
- ISSN
- 2045-2322
2045-2322
- Abstract
- To investigate the influence of preoperative smoking history on the survival outcomes and complications in a cohort from a large multicenter database. Many patients who undergo radical cystectomy (RC) have a history of smoking; however, the direct association between preoperative smoking history and survival outcomes and complications in patients with muscle-invasive bladder cancer (MIBC) who undergo robot-assisted radical cystectomy (RARC) remains unexplored. We conducted a retrospective analysis using data from 749 patients in the Korean Robot-Assisted Radical Cystectomy Study Group (KORARC) database, with an average follow-up duration of 30.8 months. The cohort was divided into two groups: smokers (n = 351) and non-smokers (n = 398). Propensity score matching was employed to address differences in sample size and baseline demographics between the two groups (n = 274, each). Comparative analyses included assessments of oncological outcomes and complications. After matching, smoking did not significantly affect the overall complication rate (p = 0.121). Preoperative smoking did not significantly increase the occurrence of complications based on complication type (p = 0.322), nor did it increase the readmission rate (p = 0.076). There were no perioperative death in either group. Furthermore, preoperative smoking history showed no significant impact on overall survival (OS) [hazard ratio (HR) = 0.87, interquartile range (IQR): 0.54–1.42; p = 0.589] and recurrence-free survival (RFS) (HR = 1.12, IQR: 0.83–1.53; p = 0.458) following RARC for MIBC. The extent of preoperative smoking (≤ 10, 10–30, and ≥ 30 pack-years) had no significant influence on OS and RFS in any of the categories (all p > 0.05). Preoperative smoking history did not significantly affect OS, RFS, or complications in patients with MIBC undergoing RARC.
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