Influence of Pretreatment with Immunosuppressive Drugs on Viral Proliferation
- Authors
- Lee, Ga-Eun; Shin, Cha-Gyun
- Issue Date
- Oct-2018
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Keywords
- Foamy virus; immunosuppressive drugs; viral replication
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.28, no.10, pp 1716 - 1722
- Pages
- 7
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 28
- Number
- 10
- Start Page
- 1716
- End Page
- 1722
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/745
- DOI
- 10.4014/jmb.1807.06054
- ISSN
- 1017-7825
1738-8872
- Abstract
- Immunosuppressive drugs are used to make the body less likely to reject transplanted organs or to treat autoimmune diseases. In this study, five immunosuppressive drugs including two glucocorticoids (dexamethasone and prednisolone), one calcineurin inhibitor (cyclosporin A), one non-steroid anti-inflammatory drug (aspirin), and one antimetabolite (methotrexate) were tested for their effects on viral proliferation using feline foamy virus (FFV). The five drugs had different cytotoxic effects on the Crandell-Ress feline kidney (CRFK) cells, the natural host cell of FFV. Dexamethasone-pretreated CRFK cells were susceptible to FFV infection, but pretreatment with prednisolone, cyclosporin A, aspirin, and methotrexate showed obvious inhibitory effects on FFV proliferation, by reducing viral production to 29.8-83.8% of that of an untreated control. These results were supported by western blot, which detected viral Gag structural protein in the infected cell lysate. As our results showed a correlation between immunosuppressive drugs and susceptibility to viral infections, it is proposed that immune-compromised individuals who are using immune-suppressive drugs may be especially vulnerable to viral infection originated from pets.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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