Effects of once-weekly dulaglutide on juvenile type 2 diabetes mellitus and obesity in Korea: a pilot studyopen access
- Authors
- Seo Ji Young; Lee Cha Gon; Choi Hoonsung; Lee Hong Kyu; Lee So Young; Kim Hyo-Jeong; Jung Kyong Yeun; Kim Jin Taek
- Issue Date
- Dec-2023
- Publisher
- 대한소아내분비학회
- Keywords
- Adolescent; Dulaglutide; Obesity; Type 2 diabetes mellitus
- Citation
- Annals of Pediatric Endocrinology & Metabolism, v.28, no.4, pp 296 - 301
- Pages
- 6
- Journal Title
- Annals of Pediatric Endocrinology & Metabolism
- Volume
- 28
- Number
- 4
- Start Page
- 296
- End Page
- 301
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74517
- DOI
- 10.6065/apem.2244196.098
- ISSN
- 2287-1012
2287-1292
- Abstract
- Purpose: We sought to investigate the effects and side effects of once-weekly dulaglutide treatment for type 2 diabetes mellitus (T2DM) in patients <18 years of age in Korea.Methods: : From the Eulji University Hospital database, we identified all patients <18 years of age diagnosed with T2DM and treated with dulaglutide from January 1, 2017, to July 31, 2022.Results: We identified 5 patients <18 years of age treated with dulaglutide for T2DM management. Their mean (standard deviation [SD]) age was 16.6 (0.5) years. Four (80%) patients were female. The mean (SD) body mass index was 29.4 (5.1) kg/m2, and the mean (SD) age at diagnosis was 15.2 (1.6) years. Four patients had been treated previously with metformin alone or in combination with insulin. Four patients were treated with 1.5 mg of dulaglutide and one was treated with 0.75 mg of dulaglutide. The mean (SD) hemoglobin A1c concentrations at baseline, 3 months after treatment, and 1 year after treatment, respectively, were 10.0% (2.2%), 6.5% (1.5%), and 6.7% (1.4%), with significant differences. In addition, at baseline, 3 months after treatment, and 1 year after treatment, the mean (SD) body weight values were 79.7 (13.3) kg, 80.2 (14.0) kg, and 81.1 (15.3) kg, with no significant difference.Conclusion: Use of once-weekly dulaglutide for juvenile T2DM ensures very good glycemic control, with few side effects and good adherence, indicating its potential as a promising therapeutic agent in this age group. Nationwide studies are warranted to confirm our results.
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