Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer
- Authors
- Lee, Soo Jin; Lee, Won Woo; Yoon, Hai-Jeon; Lee, Ho-Young; Lee, Kyoung Ho; Kim, Young Hoon; Park, Do Joong; Kim, Hyung-Ho; So, Young; Kim, Sang Eun
- Issue Date
- Jun-2013
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Gastric cancer; FDG; PET/CT; Staging
- Citation
- EUROPEAN JOURNAL OF RADIOLOGY, v.82, no.6, pp 935 - 942
- Pages
- 8
- Journal Title
- EUROPEAN JOURNAL OF RADIOLOGY
- Volume
- 82
- Number
- 6
- Start Page
- 935
- End Page
- 942
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74769
- DOI
- 10.1016/j.ejrad.2013.01.014
- ISSN
- 0720-048X
1872-7727
- Abstract
- Objective: We aimed to improve diagnostic accuracy of F-18-fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M: F = 30: 14, age +/- std = 62.1 +/- 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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