The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsyopen access
- Authors
- Lee, Chung Un; Choi, Joongwon; Sung, Si Hyun; Chung, Jae Hoon; Song, Wan; Kang, Minyong; Sung, Hyun Hwan; Jeong, Byong Chang; Seo, Seong Il; Jeon, Seong Soo; Lee, Hyun Moo; Jeon, Hwang Gyun
- Issue Date
- Nov-2021
- Publisher
- MDPI
- Keywords
- prostate biopsy; Prostate Imaging Reporting and Data System (PI-RADS); combination; targeted biopsy; systematic biopsy
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.10, no.21
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 10
- Number
- 21
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/75347
- DOI
- 10.3390/jcm10214804
- ISSN
- 2077-0383
- Abstract
- Background: To identify the role of combination biopsy, which consists of both targeted and additional systematic cores, in the diagnosis of clinically significant prostate cancer (csPCa). Methods: We retrospectively reviewed patients with PSA levels 2.5-15 ng/mL who have a suspicious prostate lesion (with the Prostate Imaging Reporting and Data System (PI-RADS) >= 3) on multiparametric MRI (mpMRI) between January 2016 and December 2018. We analyzed biopsy results by PI-RADS score and biopsy methods (systematic, targeted, and combination biopsy). Results: Of the 711 total patients, an average of 4.0 +/- 1.8 targeted and 8.6 +/- 3.1 additional systematic biopsies were performed. The additional systematic biopsies were sampled outside the targeted biopsy area. The combination biopsies detected more csPCa (201 patients, 28.3%) than did the targeted (175 patients, 24.6%) or systematic (124 patients, 17.4%) biopsies alone (p < 0.001). In the initial biopsy samples, there was a 7% increase in the detection of csPCa than in targeted biopsy (62% to 69%). It increased by 11% in repeat biopsy (46% to 57%). There was no statistical significance in both groups (p = 0.3174). Conclusions: Combination biopsy has the benefit of detecting csPCa in both initial and repeat biopsy when there is a suspicious lesion on mpMRI.
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