Impact of Combination Therapy with Ezetimibe/Simvastatin Treatment on the Neointimal Response to Biodegradable Polymer Biolimus-Eluting Stent Implantation in Patients with Acute Myocardial Infarction: Serial Assessment with Optical Coherence Tomography
DC Field | Value | Language |
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dc.contributor.author | Kim, Yongcheol | - |
dc.contributor.author | Hong, Young Joon | - |
dc.contributor.author | Kim, Sang Wook | - |
dc.contributor.author | Kim, Min Chul | - |
dc.contributor.author | Sim, Doo Sun | - |
dc.contributor.author | Kim, Ju Han | - |
dc.contributor.author | Ahn, Youngkeun | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.date.available | 2019-01-22T12:37:53Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/755 | - |
dc.description.abstract | The aim of this study was to compare the neointimal response at 12-month follow-up between ezetimibe/simvastatin (Vytorin, manufactured by Merck) 10/10 mg and Vytorin 10/40 mg after biodegradable polymer Biolimus-eluting stent (BP-BES) implantation in patients with acute myocardial infarction (AMI). A total of 20 patients requiring revascularization were randomly assigned to receive either Vytorin 10/10 mg (n = 9) or Vytorin 10/40 mg (n = 11). Baseline optical coherence tomography (OCT) was performed after stent implantation, and follow-up OCT was scheduled at 12 months. We performed follow-up OCT in 18 patients (Vytorin 10/10 mg (n = 9) or Vytorin 10/40 mg (n = 9)). A total of 842 frames and 8552 struts were analyzed at initial and follow-up OCT. At follow-up, the percentage of uncovered struts was not significantly different between both groups (6.61 +/- 10.29% vs. 7.57 +/- 6.45%, p = 0.815). The percentage of malapposed struts was also similar between both groups (0.69 +/- 1.58% vs. 1.55 +/- 2.72%, respectively, p = 0.422). Mean percent neointimal hyperplasia area was not significantly different between both groups (6.53 +/- 3.26% vs. 6.37 +/- 8.96%, p = 0.961). This OCT study showed that both high- and moderate-intensity dosing of Vytorin was associated with relatively lower percentages of uncovered struts and malapposed struts after Biolimus A9-eluting stent implantation in patients with AMI. | - |
dc.publisher | MDPI | - |
dc.title | Impact of Combination Therapy with Ezetimibe/Simvastatin Treatment on the Neointimal Response to Biodegradable Polymer Biolimus-Eluting Stent Implantation in Patients with Acute Myocardial Infarction: Serial Assessment with Optical Coherence Tomography | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/app8101968 | - |
dc.identifier.bibliographicCitation | APPLIED SCIENCES-BASEL, v.8, no.10 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000448653700263 | - |
dc.identifier.scopusid | 2-s2.0-85055085127 | - |
dc.citation.number | 10 | - |
dc.citation.title | APPLIED SCIENCES-BASEL | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | acute coronary syndrome | - |
dc.subject.keywordAuthor | ezetimibe | - |
dc.subject.keywordAuthor | simvastatin combination | - |
dc.subject.keywordAuthor | drug-eluting stent | - |
dc.subject.keywordAuthor | optical coherence tomography | - |
dc.subject.keywordPlus | CORONARY-ARTERY-DISEASE | - |
dc.subject.keywordPlus | BARE-METAL STENTS | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | THROMBOSIS | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | COVERAGE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | REGISTRY | - |
dc.subject.keywordPlus | OCT | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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