Impact of Combination Therapy with Ezetimibe/Simvastatin Treatment on the Neointimal Response to Biodegradable Polymer Biolimus-Eluting Stent Implantation in Patients with Acute Myocardial Infarction: Serial Assessment with Optical Coherence Tomographyopen access
- Authors
- Kim, Yongcheol; Hong, Young Joon; Kim, Sang Wook; Kim, Min Chul; Sim, Doo Sun; Kim, Ju Han; Ahn, Youngkeun; Jeong, Myung Ho
- Issue Date
- Oct-2018
- Publisher
- MDPI
- Keywords
- acute coronary syndrome; ezetimibe; simvastatin combination; drug-eluting stent; optical coherence tomography
- Citation
- APPLIED SCIENCES-BASEL, v.8, no.10
- Journal Title
- APPLIED SCIENCES-BASEL
- Volume
- 8
- Number
- 10
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/755
- DOI
- 10.3390/app8101968
- ISSN
- 2076-3417
2076-3417
- Abstract
- The aim of this study was to compare the neointimal response at 12-month follow-up between ezetimibe/simvastatin (Vytorin, manufactured by Merck) 10/10 mg and Vytorin 10/40 mg after biodegradable polymer Biolimus-eluting stent (BP-BES) implantation in patients with acute myocardial infarction (AMI). A total of 20 patients requiring revascularization were randomly assigned to receive either Vytorin 10/10 mg (n = 9) or Vytorin 10/40 mg (n = 11). Baseline optical coherence tomography (OCT) was performed after stent implantation, and follow-up OCT was scheduled at 12 months. We performed follow-up OCT in 18 patients (Vytorin 10/10 mg (n = 9) or Vytorin 10/40 mg (n = 9)). A total of 842 frames and 8552 struts were analyzed at initial and follow-up OCT. At follow-up, the percentage of uncovered struts was not significantly different between both groups (6.61 +/- 10.29% vs. 7.57 +/- 6.45%, p = 0.815). The percentage of malapposed struts was also similar between both groups (0.69 +/- 1.58% vs. 1.55 +/- 2.72%, respectively, p = 0.422). Mean percent neointimal hyperplasia area was not significantly different between both groups (6.53 +/- 3.26% vs. 6.37 +/- 8.96%, p = 0.961). This OCT study showed that both high- and moderate-intensity dosing of Vytorin was associated with relatively lower percentages of uncovered struts and malapposed struts after Biolimus A9-eluting stent implantation in patients with AMI.
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