Which Bisphosphonate? It’s the Compliance!: Decision Analysisopen access
- Authors
- 이유진; 박찬호; 이영균; 하용찬; 구경회
- Issue Date
- 2016
- Publisher
- 대한골대사학회
- Keywords
- Diphosphonates; Fractures bone; Osteoporosis postmenopausal; Patient compliance
- Citation
- 대한골대사학회지, v.23, no.2, pp 79 - 83
- Pages
- 5
- Journal Title
- 대한골대사학회지
- Volume
- 23
- Number
- 2
- Start Page
- 79
- End Page
- 83
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8253
- DOI
- 10.11005/jbm.2016.23.2.79
- ISSN
- 2287-6375
2287-7029
- Abstract
- Background: The best options of several bisphosphonates for prevention of osteoporotic fractures in postmenopausal women remain controversial. We determined which bisphosphonate provides better efficacy in prevention of osteoporotic fractures using a decision analysis tool, in terms of quality of life. Methods: A decision analysis model was constructed containing final outcome score and the probability of vertebral and hip fracture within 1 year. Final outcome was defined as health-related quality of life, and was used as an utility in the decision tree. Probabilities were obtained by literature review, and health-related quality of life was evaluated by consensus committee. A roll back tool was used to determine the best bisphosphonate, and sensitivity analysis was performed to compensate for decision model uncertainty. Results: The decision model favored bisphosphonate with higher compliance in terms of quality of life. In one-way sensitivity analysis, ibandronate was more beneficial than the others, when probability of compliance on ibandronate was above 0.589. Conclusions: In terms of quality of life, the decision analysis model showed that compliance was most important for patients in real world, regardless of type of bisphosphonate.
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