Comparison of propofol monotherapy and propofol combination therapy for sedation during gastrointestinal endoscopy: A systematic review and meta-analysis
- Authors
- Yoon, Sang Won; Choi, Geun Joo; Lee, Oh Haeng; Yoon, Il Jae; Kang, Hyun; Baek, Chong Wha; Jung, Yong Hun; Woo, Young Cheol
- Issue Date
- Sep-2018
- Publisher
- WILEY
- Keywords
- digestive system; endoscopy; gastrointestinal; propofol; sedation
- Citation
- DIGESTIVE ENDOSCOPY, v.30, no.5, pp 580 - 591
- Pages
- 12
- Journal Title
- DIGESTIVE ENDOSCOPY
- Volume
- 30
- Number
- 5
- Start Page
- 580
- End Page
- 591
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/828
- DOI
- 10.1111/den.13050
- ISSN
- 0915-5635
1443-1661
- Abstract
- Background and AimPrevious randomized controlled trials have reported conflicting findings comparing propofol combination therapy (PCT) with propofol monotherapy (PMT) for sedation of patients undergoing gastrointestinal endoscopy. Therefore, a systematic review was carried out to compare the efficacy and safety of PCT and PMT in such patients. MethodsWe searched MEDLINE, EMBASE and CENTRAL databases to identify all randomized controlled trials that compared the efficacy and safety of PCT and PMT for sedation of patients undergoing gastrointestinal endoscopy. Primary endpoints were incidence of respiratory complications, hypotension and arrhythmia, dose of propofol used, and recovery time. Procedure duration and the satisfaction of patients and doctors were also evaluated. ResultsA total of 2250 patients from 22 studies were included in the final analysis. The combined analysis did not show any difference between PCT and PMT in the incidence of respiratory complications (risk ratio [RR], 0.80; 95% CI, 0.52 to 1.23; I-2 = 58.34%), hypotension (RR, 1.06; 95% CI, 0.63 to 1.78; I-2 = 72.13%), arrhythmia (RR,1.40; 95% CI, 0.74 to 2.64; I-2 = 43.71%), recovery time (standardized mean difference [SMD], 0.16; 95% CI, -0.49 to 0.81; I-2 = 95.9%), procedure duration (SMD, 0.04; 95% CI, -0.05 to 0.14; I-2 = 0.0%), patient satisfaction (SMD, 0.13; 95% CI, -0.26 to 0.52; I-2 = 89.63%) or doctor satisfaction (SMD, 0.01; 95% CI, -0.15 to 0.17; I-2 = 0.00%). However, the dose of propofol used was significantly lower in PCT than in PMT (SMD, -1.38; 95% CI, -1.99 to -0.77; I-2 = 97.70%). ConclusionPCT showed comparable efficacy and safety to PMT with respect to respiratory complications, hypotension and arrhythmia, recovery time, procedure duration, patient satisfaction, and doctor satisfaction. However, the average dose of propofol used was higher in PMT.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/828)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.