Inhibitory effects of the aerial parts of Epimedium koreanum on TPA-induced inflammation and tumour promotion in two-stage carcinogenesis in mouse skin
- Authors
- Yasukawa, K.; Ko, S.-K.; Whang, W.-K.
- Issue Date
- 2016
- Publisher
- Lifescience Global
- Keywords
- Antitumour-promoting activity; Cancer chemoprevention; Epimedium koreanum; Prenyl flavonol glycosides; Two-stage carcinogenesis
- Citation
- Journal of Pharmacy and Nutrition Sciences, v.6, no.2, pp 38 - 42
- Pages
- 5
- Journal Title
- Journal of Pharmacy and Nutrition Sciences
- Volume
- 6
- Number
- 2
- Start Page
- 38
- End Page
- 42
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8582
- DOI
- 10.6000/1927-5951.2016.06.02.1
- ISSN
- 2223-3806
1927-5951
- Abstract
- Cancer prevention by supplements offers the most cost-effective long-term health strategy. Methanol extracts from the aerial parts of Epimedium koreanum were previously found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory ear oedema and tumour promotion by TPA in the two-stage mouse skin carcinogenesis model. Four prenyl flavonol glycosides (1-4) were isolated from the active fraction of this extract, and were identified. The isolated compounds showed inhibitory activity against TPA-induced ear inflammatory ear oedema. The 50% inhibitory dose (ID50) of icariin (1), epimedin A (2), epimedin B (3) and epimedin C (4) for TPA-induced inflammation ranged from 114 to 255 nmol/ear, suggesting greater potency than indomethacin (ID50: 908 nmol/ear), an antiinflammatory drug. Thus, the epimedium herb may be useful in cancer prevention. © 2016 Lifescience Global.
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