Antioxidative and Antitumor Effects of Isoflavones Isolated from the Leaves of Maackia fauriei.
DC Field | Value | Language |
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dc.contributor.author | Yoon, Ki Hoon | - |
dc.contributor.author | Park, Kwang Jun | - |
dc.contributor.author | Yin, Jun | - |
dc.contributor.author | Yoon, Kyu Hyung | - |
dc.contributor.author | Lee, Ji Yeon | - |
dc.contributor.author | Hwang, Yoon Jeong | - |
dc.contributor.author | Lee, Do Ik | - |
dc.contributor.author | Choi, Young Wook | - |
dc.contributor.author | Lee, Min Won | - |
dc.date.available | 2019-03-08T15:57:41Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1307-6167 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8676 | - |
dc.description.abstract | The flowers of Maackia fauriei have traditionally been used to treat hypertension, apoplexy, hemostasis, vaginal bleeding, and dystocia; moreover, the bark of this plant has been used as a natural dye. In the present study, activity-guided isolation of the leaves of M. fauriei yielded five isoflavones [genistein (1), pratensein (2), genistin (3), 2'-hydroxygenistein-7-O-beta-D-glucopyranoside (4), and 2,3-dehydrokievitone (5)]; three pterocarpans [medicarpin (6), maackiain (7), and 4-hydroxy maackiain (8)]; and one flavonol [isoquercitrin (9)]. To evaluate the anti-oxidative effects of these compounds, their 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assays and nitrotetrazolium blue chloride (NBT) superoxide scavenging assays were measured. And the anti-tumor activity against human cancer cell lines in genital system, LNCaP, PC-3, HeLa and OVCAR-3 cells were evaluated by MTT method. Furthermore, the apoptosis of the PC-3 and HeLa cells were determined by by annexin V-FITC and PI their fluorescence was analyzed by flow cytometry. The flavonol (9, isoquercitrin) and pterocarpan (8, 4-hydroxymaackiain) showed strong anti-oxidative activities. Besides, the isoflavones (1-5) did not showed anti-oxidative activity and the isoflavones (1-5) and pterocarpans (6-8) generally showed the potent cytotoxic activity against all of four human genital cancer cells. Especially, 2,3-dehydrokievitone (5) which had a prenyl group at C-8 position of the A-ring exhibited strong cytotoxic activity and induced apoptosis efficiently in cancer cells. (C) 2016 ACG Publications. All rights reserved. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACG PUBLICATIONS | - |
dc.title | Antioxidative and Antitumor Effects of Isoflavones Isolated from the Leaves of Maackia fauriei. | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | RECORDS OF NATURAL PRODUCTS, v.10, no.4, pp 441 - 451 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000372803800005 | - |
dc.identifier.scopusid | 2-s2.0-84952882514 | - |
dc.citation.endPage | 451 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 441 | - |
dc.citation.title | RECORDS OF NATURAL PRODUCTS | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 터키 | - |
dc.subject.keywordAuthor | Maackia fauriei | - |
dc.subject.keywordAuthor | flavonoids | - |
dc.subject.keywordAuthor | pterocarpans | - |
dc.subject.keywordAuthor | anti-oxidant | - |
dc.subject.keywordAuthor | anti-tumor | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | POLYPHENOLS | - |
dc.subject.keywordPlus | ROOTS | - |
dc.subject.keywordPlus | LINES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ACID | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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