Pericyte-targeting drug delivery and tissue engineeringopen access
- Authors
- Kang, Eunah; Shin, Jong Wook
- Issue Date
- May-2016
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- pericytes; pericyte-targeting drug delivery; tissue engineering; platelet-derived growth factor; angiogenesis; vascular remodeling
- Citation
- INTERNATIONAL JOURNAL OF NANOMEDICINE, v.11, pp 2397 - 2406
- Pages
- 10
- Journal Title
- INTERNATIONAL JOURNAL OF NANOMEDICINE
- Volume
- 11
- Start Page
- 2397
- End Page
- 2406
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8691
- DOI
- 10.2147/IJN.S105274
- ISSN
- 1178-2013
1178-2013
- Abstract
- Pericytes are contractile mural cells that wrap around the endothelial cells of capillaries and venules. Depending on the triggers by cellular signals, pericytes have specific functionality in tumor microenvironments, properties of potent stem cells, and plasticity in cellular pathology. These features of pericytes can be activated for the promotion or reduction of angiogenesis. Frontier studies have exploited pericyte-targeting drug delivery, using pericyte-specific peptides, small molecules, and DNA in tumor therapy. Moreover, the communication between pericytes and endothelial cells has been applied to the induction of vessel neoformation in tissue engineering. Pericytes may prove to be a novel target for tumor therapy and tissue engineering. The present paper specifically reviews pericyte-specific drug delivery and tissue engineering, allowing insight into the emerging research targeting pericytes.
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- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
- College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
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