Irradiation with 310 nm and 340 nm ultraviolet light-emitting-diodes can improve atopic dermatitis-like skin lesions in NC/Nga mice
- Authors
- Kwon, Tae-Rin; Kim, Jong Hwan; Hong, Ji-Yeon; Seok, Joon; Kim, Jae Min; Bak, Dong-Ho; Choi, Mi-Ji; Mun, Seok Kyun; Kim, Chan Woong; Kim, Beom Joon
- Issue Date
- Oct-2018
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, v.17, no.8, pp 1127 - 1135
- Pages
- 9
- Journal Title
- PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
- Volume
- 17
- Number
- 8
- Start Page
- 1127
- End Page
- 1135
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/906
- DOI
- 10.1039/c8pp00063h
- ISSN
- 1474-905X
1474-9092
- Abstract
- Ultraviolet (UV) light produces an immunomodulatory effect on the skin and is widely used for the treatment of chronic inflammatory skin diseases. UV light emitting diodes (UV-LEDs) are a new and promising source of UV radiation. However, their mechanism of action remains largely unknown. In this study, we tested the safety and effectiveness of UV-LED irradiation for the treatment of atopic dermatitis (AD) in an NC/Nga mouse model. Mice were divided into seven groups of eight mice each. Application of Dermatophagoides farinae (Df) extract ointment for four weeks induced AD-like skin lesions. Subsequently, the mice were exposed to UV-LEDs, narrow band UVB, or UVA irradiation three times per week. We assessed the immunosuppressive effects of 310 nm (50 mJ cm(-2)) and 340 nm (5 J cm(-2)) UV-LED irradiation. Histological analyses using hematoxylin-eosin, toluidine blue, and immunohistochemical staining were performed. In addition, the serum levels of IgE, inflammatory cytokines and chemokines were measured using enzyme-linked immunosorbent assays (ELISAs). UV-LED irradiation significantly alleviated AD-like skin symptoms, including edema, erythema, dryness, and itching, by modulating Th1 and Th2 responses, transepidermal water loss (TEWL), and scratching behavior in NC/Nga mice. These results suggest that UV-LEDs can improve the treatment of inflammatory skin diseases.
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