The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse
- Authors
- Xu, Mei Ling; Kim, Hyoung Jin; Wi, Ga Ram; Kim, Hong-Jin
- Issue Date
- Sep-2015
- Publisher
- MICROBIOLOGICAL SOCIETY KOREA
- Keywords
- bovine colostrum; CD8 T cell; respiratory syncytial virus
- Citation
- JOURNAL OF MICROBIOLOGY, v.53, no.9, pp 661 - 666
- Pages
- 6
- Journal Title
- JOURNAL OF MICROBIOLOGY
- Volume
- 53
- Number
- 9
- Start Page
- 661
- End Page
- 666
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9163
- DOI
- 10.1007/s12275-015-5353-4
- ISSN
- 1225-8873
1976-3794
- Abstract
- Human respiratory syncytial virus (hRSV) is the most common cause of respiratory tract infection among young children because of immature T cell immunity of them against hRSV. CD8 T cells play a pivotal role in clearing hRSV and preventing subsequent infection. We examined the effects of dietary bovine colostrum on virus infection and CD8 T cell responses following hRSV infection in the mouse model. Mice received bovine colostrum for 14 days prior to hRSV challenge, and lung indexes (severity of symptom) and lung virus titers were analyzed. In addition, the activation of CD8 T cells in the bronchoalveolar lavage fluids (BALFs) of mice receiving bovine colostrum were compared with those in the BALFs of mice receiving phosphate-buffered saline (PBS) or ribavirin, post virus challenge. The severity of infection and lung virus titers were reduced in the mice receiving bovine colostrum, compared to those receiving PBS. Moreover CD8 T cell responses were selectively enhanced in the former. Our results suggest that dietary bovine colostrum exerts the effects to inhibit hRSV and ameliorate the symptom by hRSV infection, and enhances the CD8 T cell response during the hRSV infection.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.