Single nucleotide polymorphisms in DKK3 gene are associated with prostate cancer risk and progression
- Authors
- Kim, Min Su; Lee, Ha Na; Kim, Hae Jong; Myung, Soon Chul
- Issue Date
- Sep-2015
- Publisher
- BRAZILIAN SOC UROL
- Keywords
- Biological Markers; Genetic Variation; Prostatic Neoplasms; Polymorphism; Single Nucleotide
- Citation
- INTERNATIONAL BRAZ J UROL, v.41, no.5, pp 869 - 897
- Pages
- 29
- Journal Title
- INTERNATIONAL BRAZ J UROL
- Volume
- 41
- Number
- 5
- Start Page
- 869
- End Page
- 897
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9211
- DOI
- 10.1590/S1677-5538.IBJU.2014.0041
- ISSN
- 1677-5538
1677-6119
- Abstract
- We had investigated whether sequence variants within DKK3 gene are associated with the development of prostate cancer in a Korean study cohort. We evaluated the association between 53 single nucleotide polymorphisms (SNPs) in the DKK3 gene and prostate cancer risk as well as clinical characteristics (PSA, clinical stage, pathological stage and Gleason score) in Korean men (272 prostate cancer subjects and 173 benign prostate hyperplasia subjects) using unconditional logistic regression analysis. Of the 53 SNPs and 25 common haplotypes, 5 SNPs and 4 haplotypes were associated with prostate cancer risk (P= 0.02-0.04); 3 SNPs and 2 haplotypes were significantly associated with susceptibility to prostate cancer, however 2 SNPs and 2 haplotypes exhibited a significant protective effect on prostate cancer. Logistic analyses of the DKK3 gene polymorphisms with several prostate cancer related factors showed that several SNPs were significant; three SNPs and two haplotypes to PSA level, three SNPs and two haplotypes to clinical stage, nine SNPs and two haplotype to pathological stage, one SNP and one haplotypes to Gleason score. To the author's knowledge, this is the first report documenting that DKK3 polymorphisms are not only associated with prostate cancer but also related to prostate cancer-related factors.
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