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Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3Bopen access
- Issue Date
- Jul-2015
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- ANGPT1; Cell motility; KDM3B; SMRT; Transcription
- Citation
- BMB REPORTS, v.48, no.7, pp 401 - 406
- Pages
- 6
- Journal Title
- BMB REPORTS
- Volume
- 48
- Number
- 7
- Start Page
- 401
- End Page
- 406
- ISSN
- 1976-6696
1976-670X
- Abstract
- Here we report that the H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. Negative regulation of ANGPT1 by KDM3B is independent of its Jumonji (JmjC) domain-mediated H3K9 demethylase activity. We demonstrate that KDM3B downregulates ANGPT1 via interaction with SMRT, and suggest that the repressor complex is formed at the promoter area of ANGPT1. Using MTT and wound healing assays, depletion of KDM3B was found to increase cell proliferation and cell motility, indicating that KDM3B has a role in angiogenesis.
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