Plant-derived molecules from Saussurea grandifolia as inhibitors of aldose reductase
- Authors
- Kim, Hye Min; Lee, Dong Gu; Lee, Sanghyun
- Issue Date
- Jun-2015
- Publisher
- KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
- Keywords
- Saussurea grandifolia; Aldose reductase; Flavonoid; Phenylpropanoid
- Citation
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.58, no.3, pp 365 - 371
- Pages
- 7
- Journal Title
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
- Volume
- 58
- Number
- 3
- Start Page
- 365
- End Page
- 371
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9469
- DOI
- 10.1007/s13765-015-0051-9
- ISSN
- 1738-2203
2234-344X
- Abstract
- Saussurea grandifolia was tested for aldose reductase (AR) inhibition as part of a search for potentially therapeutic natural compounds. Stepwise polarity fractions were tested for in vitro inhibition of rat lens AR. Of these, the ethyl acetate (EtOAc) and n-butanol (n-BuOH) fractions exhibited AR inhibitory activities. A chromatographic separation of the active EtOAc and n-BuOH fractions led to the isolation of nine compounds, which were known and identified as vitexin (1), genkwanin-5-O-glucoside (2), vitexin 2 ''-p- hydroxybenzoate (3), kaempferol-3-O-rutinoside (4), isovitexin (5), quercitrin (6), isoquercitrin (7), 1,5-di-O-caffeoylquinic acid (8), and vicenin 1 (9). Among these compounds, compounds 6, 7, and 8 showed very strong inhibitory activities against AR (IC50 's = 0.34, 0.32, and 0.08 mu M, respectively). The results suggest that S. grandifolia is clearly a potential source for therapeutic agent that might be useful for the treatment of diabetic complications.
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