PROTECTIVE EFFECT OF BLUEBERRY LEAF METHANOLIC EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED DAMAGE IN PC-12 CELLS
- Authors
- Lee, Seung-Jae; Lee, Seung Yuan; Bahk, Young Yil; Hur, Sun Jin
- Issue Date
- May-2015
- Publisher
- NEW CENTURY HEALTH PUBLISHERS, LLC
- Keywords
- Antioxidant activity; Blueberry leaves; Neuroprotective effect; Oxidative damage; PC-12 cells
- Citation
- CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, v.13, no.2, pp 77 - 82
- Pages
- 6
- Journal Title
- CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
- Volume
- 13
- Number
- 2
- Start Page
- 77
- End Page
- 82
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9641
- ISSN
- 1540-7535
2641-452X
- Abstract
- The purpose of this study was to evaluate the antioxidative activities of methanolic extracts from blueberry leaves (MEBL). The total polyphenol and flavonoid content of MEBL was 139.27 +/- 4.15 milligram gallic acid equivalents (mg GAE/g) and 126.44 +/- 3.80 catechin equivalents in milligram per gram (mg CE/g), respectively. The antioxidant effects of MEBL were evaluated, including 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP). We also evaluated the protection effect on hydroxyl radical-induced oxidative damage in PC-12 cells via propidium iodide staining using a flow cytometer MEBL decreased cell death in PC-12 cells due to hydroxyl radical-induced oxidative damage in a dose-dependent manner. In addition, MEBL regulated the expression of Bcl-2 and Bax proteins in PC-12 cells. The findings of this study suggested that MEBL has the potential to protect against hydrogen peroxide-induced cell damage and should be considered as a prospective functional food.
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