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Leucine-rich glioma inactivated 3 and tumor necrosis factor-α regulate mutually through NF-κB

Authors
Kim, Hyun A.Kwon, Nyoun SooBaek, Kwang JinKim, Dong-SeokYun, Hye-Young
Issue Date
Apr-2015
Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Keywords
LGI3; TNF-alpha; NF-kappa B; Adipokine; Obesity
Citation
CYTOKINE, v.72, no.2, pp 220 - 223
Pages
4
Journal Title
CYTOKINE
Volume
72
Number
2
Start Page
220
End Page
223
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9684
DOI
10.1016/j.cyto.2014.12.023
ISSN
1043-4666
1096-0023
Abstract
Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein member of LGI family. We previously reported that LGI3 increased in obese adipose tissues and suppressed adipogenesis through its receptor, ADAM23. We proposed that LGI3 may be a pro-inflammatory adipokine secreted predominantly by preadipocytes and macrophages. In this study, we showed that LGI3 and tumor necrosis factor-alpha (TNF-alpha) upregulated each other in 3T3-L1 cells. Treatment of 3T3-L1 preadipocytes with LGI3 protein increased TNF-alpha mRNA and protein. LGI3 treatment led to NF-kappa B activation and binding to an NF-kappa B binding site (-523 to -514) in TNF-alpha promoter. TNF-alpha treatment increased mRNA and protein expression of LGI3 and ADAM23. TNF-alpha increased NF-kappa B binding to a predicted binding site (-40 to -31) in LGI3 promoter. High fat diet-fed mice showed that LGI3 and TNF-alpha were increased and colocalized in adipose tissue inflammation. Taken together, these results suggested that mutual upregulation of LGI3 and TNF-alpha may play a role in adipose tissue inflammation in obesity. (C) 2015 Elsevier Ltd. All rights reserved.
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