PATTERN DIFFERENCE OF DISSOCIATED HAND MUSCLE ATROPHY IN AMYOTROPHIC LATERAL SCLEROSIS AND VARIANTS
- Authors
- Kim, Jee-Eun; Hong, Yoon-Ho; Lee, Joon-Hyung; Ahn, Suk-Won; Kim, Sung-Min; Park, Kyung-Seok; Sung, Jung-Joon; Lee, Kwang-Woo; Seong, Seung-Yong
- Issue Date
- Mar-2015
- Publisher
- WILEY
- Keywords
- amyotrophic lateral sclerosis; brachial amyotrophic diplegia; Hirayama disease; progressive muscular atrophy; split hand
- Citation
- MUSCLE & NERVE, v.51, no.3, pp 333 - 337
- Pages
- 5
- Journal Title
- MUSCLE & NERVE
- Volume
- 51
- Number
- 3
- Start Page
- 333
- End Page
- 337
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9790
- DOI
- 10.1002/mus.24323
- ISSN
- 0148-639X
1097-4598
- Abstract
- Introduction: Split hand is considered to be a specific feature of amyotrophic lateral sclerosis (ALS). Methods: We evaluated the pattern difference of intrinsic hand muscles of upper limb-onset ALS (UL-ALS), upper limb-onset progressive muscular atrophy (UL-PMA), brachial amyotrophic diplegia (BAD), and Hirayama disease (HD) by measuring objective electrophysiological markers. Results: The abductor digiti minimi (ADM)/abductor pollicis brevis (APB) compound muscle action potential (CMAP) amplitude ratio was significantly higher in UL-ALS than other variants, but a considerable proportion of UL-ALS cases had an amplitude ratio in the range of other variants. Absent APB CMAP and abnormally high ADM/APB CMAP amplitude ratio (4) occurred only with UL-ALS. Conversely, an absent ADM CMAP was identified only in UL-PMA and BAD. Conclusions: The absolute ADM/APB CMAP amplitude ratio was not specific for ALS; however, several findings from simple electrophysiological measurements may help predict prognosis in patients with motor neuron diseases and may be early diagnostic markers for ALS. Muscle Nerve 51: 333-337, 2015
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